CLINICAL TRIALS PROFILE FOR ATOVAQUONE AND PROGUANIL HYDROCHLORIDE

All Clinical Trials for ATOVAQUONE AND PROGUANIL HYDROCHLORIDE

Trial ID	Title	Status	Sponsor	Phase	Start Date	Summary
NCT00084227 ↗	Azithromycin Plus Chloroquine Versus Atovaquone-Proguanil For The Treatment Of Uncomplicated Plasmodium Falciparum Malaria In South America	Completed	Pfizer	Phase 2/Phase 3	2004-07-01	The primary objective is to confirm the hypothesis that azithromycin plus chloroquine is non-inferior to atovaquone-proguanil for the treatment of symptomatic, uncomplicated malaria due to P. falciparum.
NCT00149383 ↗	Safety and Efficacy Study of Adjunctive Rosiglitazone in the Treatment of Uncomplicated Falciparum Malaria	Completed	McLaughlin-Rotman Center for Global Health, University of Toronto	Phase 1/Phase 2	2004-12-01	The purpose of this study is to examine the safety, tolerability, and efficacy of adjunctive rosiglitazone in the treatment of uncomplicated P.falciparum malaria.
NCT00149383 ↗	Safety and Efficacy Study of Adjunctive Rosiglitazone in the Treatment of Uncomplicated Falciparum Malaria	Completed	Mahidol University	Phase 1/Phase 2	2004-12-01	The purpose of this study is to examine the safety, tolerability, and efficacy of adjunctive rosiglitazone in the treatment of uncomplicated P.falciparum malaria.
NCT00379821 ↗	Chloroquine Alone or in Combination for Malaria in Children in Malawi	Completed	National Institute of Allergy and Infectious Diseases (NIAID)	Phase 3	2007-02-01	Malaria is a sickness caused by a germ that can get into a person's body when a mosquito bites them. It can cause fever, headache, body aches and weakness. It can even cause death, especially in children. When malaria is treated with the appropriate medicine(s), it can be cured completely. The purpose of this study is to find out if it is better to use chloroquine alone or in combination with another drug to most effectively treat malaria. About 640 children with malaria, aged 6 months to 5 years of age, from the Blantyre Malaria Project Research Clinic at the Ndirande Health Center in Malawi will be in the study. They will be treated with either chloroquine alone or a combination of chloroquine plus another medication (azithromycin or artesunate or atovaquone-proguanil) every time they get malaria for a year. Blood samples will be collected and tested at least every 4 weeks. Participants will be involved in the study for 1 year.
NCT00386750 ↗	Safety of Artemether - Lumefantrine, and Other Malaria Drugs and Their Effect on the Auditory Function	Terminated	Novartis Pharmaceuticals	Phase 4	2005-06-01	THIS STUDY IS NOT ENROLLING PATIENTS IN THE USA. To evaluate the effects of artemether/ lumefantrine on the auditory function.
NCT00421473 ↗	Drug Interaction Study Between Atovaquone and Antiretroviral Agents in HIV-1 Infected Patients	Completed	Radboud University	Phase 4	2007-03-01	Malarone® (atovaquone/proguanil) is frequently used in malaria prophylaxis. Unfortunately, there are indications that certain anti-HIV agents may decrease atovaquone plasma levels by induction of atovaquone metabolism. For travelling HIV patients, the clinical consequences of these possible drug drug interactions are serious, since a diminished exposure to the anti-malarial drug will result in suboptimal prophylaxis of malaria and potential development of drug resistant strains of Plasmodium falciparum. The purpose of this study is to find out if HIV patients using HAART regimes with either lopinavir/ritonavir, atazanavir/ritonavir or efavirenz have lower atovaquone plasma levels than healthy volunteers after a single dose of atovaquone/proguanil.
NCT00444106 ↗	Evaluation of Potential Effect of Artemether - Lumefantrine and Malaria Drugs on Auditory Function	Completed	Novartis	Phase 4	2007-05-01	To evaluate the potential effects of artemether- lumefantrine on the auditory function

Clinical Trial Conditions for ATOVAQUONE AND PROGUANIL HYDROCHLORIDE

Condition Name

Condition Name for ATOVAQUONE AND PROGUANIL HYDROCHLORIDE
Intervention	Trials
Malaria	12
Malaria, Falciparum	2
Malaria,Falciparum	2
Controlled Human Malaria Infection	2

Condition MeSH

Condition MeSH for ATOVAQUONE AND PROGUANIL HYDROCHLORIDE
Intervention	Trials
Malaria	21
Malaria, Falciparum	7
Infections	2
Infection	2

Clinical Trial Locations for ATOVAQUONE AND PROGUANIL HYDROCHLORIDE

Trials by Country

Trials by Country for ATOVAQUONE AND PROGUANIL HYDROCHLORIDE
Location	Trials
Netherlands	6
Thailand	3
United States	3
Cambodia	2
Malaysia	1

Trials by US State

Trials by US State for ATOVAQUONE AND PROGUANIL HYDROCHLORIDE
Location	Trials
Maryland	3

Clinical Trial Progress for ATOVAQUONE AND PROGUANIL HYDROCHLORIDE

Clinical Trial Phase

Clinical Trial Phase for ATOVAQUONE AND PROGUANIL HYDROCHLORIDE
Clinical Trial Phase	Trials
Phase 4	9
Phase 3	2
Phase 2/Phase 3	1

Clinical Trial Status

Clinical Trial Status for ATOVAQUONE AND PROGUANIL HYDROCHLORIDE
Clinical Trial Phase	Trials
Completed	17
Terminated	3
Not yet recruiting	2

Clinical Trial Sponsors for ATOVAQUONE AND PROGUANIL HYDROCHLORIDE

Sponsor Name

Sponsor Name for ATOVAQUONE AND PROGUANIL HYDROCHLORIDE
Sponsor	Trials
Radboud University	4
Medicines for Malaria Venture	3
The PATH Malaria Vaccine Initiative (MVI)	3

Sponsor Type

Sponsor Type for ATOVAQUONE AND PROGUANIL HYDROCHLORIDE
Sponsor	Trials
Other	35
Industry	9
U.S. Fed	5