Treatment of Acyclovir-Resistant Mucocutaneous Herpes Simplex Disease in Patients With AIDS: Open Label Pilot Study of Topical Trifluridine
Completed
Glaxo Wellcome
N/A
1969-12-31
To determine the safety, effectiveness, and toxicity of topical (local) trifluridine in
treating mucocutaneous (at the nasal, oral, vaginal, and anal openings) Herpes simplex virus
( HSV ) disease that has shown resistance to acyclovir in HIV-infected patients. HSV
infection in patients with AIDS is often associated with skin sores and frequent recurrences.
Treatment with the drug acyclovir results in healing for most patients, but repeated
treatment sometimes results in resistance of the virus to acyclovir. Thus, when this happens,
other treatments need to be used. Trifluridine is an antiviral drug that is used for the
treatment of Herpes infections that occur in the eye. This study attempts to determine if
trifluridine is useful for treating HSV sores that have not healed after treatment with
acyclovir.
Treatment of Acyclovir-Resistant Mucocutaneous Herpes Simplex Disease in Patients With AIDS: Open Label Pilot Study of Topical Trifluridine
Completed
National Institute of Allergy and Infectious Diseases (NIAID)
N/A
1969-12-31
To determine the safety, effectiveness, and toxicity of topical (local) trifluridine in
treating mucocutaneous (at the nasal, oral, vaginal, and anal openings) Herpes simplex virus
( HSV ) disease that has shown resistance to acyclovir in HIV-infected patients. HSV
infection in patients with AIDS is often associated with skin sores and frequent recurrences.
Treatment with the drug acyclovir results in healing for most patients, but repeated
treatment sometimes results in resistance of the virus to acyclovir. Thus, when this happens,
other treatments need to be used. Trifluridine is an antiviral drug that is used for the
treatment of Herpes infections that occur in the eye. This study attempts to determine if
trifluridine is useful for treating HSV sores that have not healed after treatment with
acyclovir.
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