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Last Updated: November 8, 2024

CLINICAL TRIALS PROFILE FOR BAQSIMI


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505(b)(2) Clinical Trials for BAQSIMI

This table shows clinical trials for potential 505(b)(2) applications. See the next table for all clinical trials
Trial Type Trial ID Title Status Sponsor Phase Start Date Summary
New Formulation NCT05206149 ↗ Stimulation Test With Intranasal Glucagon for Corticotroph, Somatotroph and Antidiuretic Axes Completed Azienda Ospedaliera Città della Salute e della Scienza di Torino Phase 4 2021-10-01 The diagnosis of secondary hypoadrenalism and GH deficiency (GHD) often requires the performance of a dynamic test. The glucagon stimulation test (GST) is one of the options for evaluating hypothalamic-pituitary function, representing a stimulus for both the corticotropic and somatotropic axis, substantially safe and easily available. The standard procedure involves the intramuscular injection of 1-1.5 mg of glucagon based on the patient's weight. In addition to its antero-pituitary function, glucagon has also shown its ability to stimulate neurohypophyseal secretion. Using the copeptin dosage, it has been shown that after the administration of glucagon in healthy subjects there is a significant release of ADH. However, the available data are scarse and there is no standardized protocol for the use of the glucagon test in diabetes insipidus. At the moment, GST is not the most frequently chosen diagnostic option. In fact, despite having the advantage of being able to investigate different areas of anterohypophyseal and probably posterohypophyseal function at the same time, the test has some disadvantages: the prolonged duration makes the procedure challenging, the intramuscular injection can be unwelcome, and many variables can come into play in the definition of a normal response (age, BMI, glycemic status). The recent introduction of a single-dose nasal powder formulation (Baqsimi®) could overcome some of the limitations of classic GST and make the procedure less demanding. To date, no assessments are yet available regarding a purely diagnostic role in the context of hypopituitarism of this new formulation. Through the knowledge of the physiological response of the adrenocortical, somatotropic and ADH axis to the administration of intranasal glucagon in healthy subjects, it will be possible to evaluate its possible application in the diagnosis of GH deficiency, central adrenal insufficiency and possibly diabetes insipidus.
>Trial Type >Trial ID >Title >Status >Phase >Start Date >Summary

All Clinical Trials for BAQSIMI

Trial ID Title Status Sponsor Phase Start Date Summary
NCT04992312 ↗ A Study of Nasal Glucagon (LY900018) in Pediatric Participants With Type 1 Diabetes Not yet recruiting Eli Lilly and Company Phase 1 2021-12-06 The main purpose of this study is to evaluate the safety and tolerability of a study drug called nasal glucagon (Baqsimi) in pediatric participants with type 1 diabetes (T1D) aged 1 to less than 4 years. Blood tests will be performed to check how much nasal glucagon gets into the bloodstream. Blood sugar will also be measured to understand the effect of the drug on blood sugar levels. The study consists of a screening period up to 35 days before dosing, 1 day when a dose of nasal glucagon will be given and then 2 telephone follow up calls; first follow-up call on the day after the nasal glucagon was given and second call about one week after nasal glucagon was given. The study will last up to 9 days, not including the screening period.
NCT05206149 ↗ Stimulation Test With Intranasal Glucagon for Corticotroph, Somatotroph and Antidiuretic Axes Completed Azienda Ospedaliera Città della Salute e della Scienza di Torino Phase 4 2021-10-01 The diagnosis of secondary hypoadrenalism and GH deficiency (GHD) often requires the performance of a dynamic test. The glucagon stimulation test (GST) is one of the options for evaluating hypothalamic-pituitary function, representing a stimulus for both the corticotropic and somatotropic axis, substantially safe and easily available. The standard procedure involves the intramuscular injection of 1-1.5 mg of glucagon based on the patient's weight. In addition to its antero-pituitary function, glucagon has also shown its ability to stimulate neurohypophyseal secretion. Using the copeptin dosage, it has been shown that after the administration of glucagon in healthy subjects there is a significant release of ADH. However, the available data are scarse and there is no standardized protocol for the use of the glucagon test in diabetes insipidus. At the moment, GST is not the most frequently chosen diagnostic option. In fact, despite having the advantage of being able to investigate different areas of anterohypophyseal and probably posterohypophyseal function at the same time, the test has some disadvantages: the prolonged duration makes the procedure challenging, the intramuscular injection can be unwelcome, and many variables can come into play in the definition of a normal response (age, BMI, glycemic status). The recent introduction of a single-dose nasal powder formulation (Baqsimi®) could overcome some of the limitations of classic GST and make the procedure less demanding. To date, no assessments are yet available regarding a purely diagnostic role in the context of hypopituitarism of this new formulation. Through the knowledge of the physiological response of the adrenocortical, somatotropic and ADH axis to the administration of intranasal glucagon in healthy subjects, it will be possible to evaluate its possible application in the diagnosis of GH deficiency, central adrenal insufficiency and possibly diabetes insipidus.
>Trial ID >Title >Status >Phase >Start Date >Summary

Clinical Trial Conditions for BAQSIMI

Condition Name

Condition Name for BAQSIMI
Intervention Trials
Hypopituitarism 1
Type 1 Diabetes 1
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Condition MeSH

Condition MeSH for BAQSIMI
Intervention Trials
Hypopituitarism 1
Diabetes Mellitus, Type 1 1
Diabetes Mellitus 1
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Clinical Trial Locations for BAQSIMI

Trials by Country

Trials by Country for BAQSIMI
Location Trials
United States 7
Italy 1
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Trials by US State

Trials by US State for BAQSIMI
Location Trials
Pennsylvania 1
Ohio 1
New York 1
Missouri 1
Indiana 1
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Clinical Trial Progress for BAQSIMI

Clinical Trial Phase

Clinical Trial Phase for BAQSIMI
Clinical Trial Phase Trials
Phase 4 1
Phase 1 1
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Clinical Trial Status

Clinical Trial Status for BAQSIMI
Clinical Trial Phase Trials
Completed 1
Not yet recruiting 1
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Clinical Trial Sponsors for BAQSIMI

Sponsor Name

Sponsor Name for BAQSIMI
Sponsor Trials
Eli Lilly and Company 1
Azienda Ospedaliera Città della Salute e della Scienza di Torino 1
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Sponsor Type

Sponsor Type for BAQSIMI
Sponsor Trials
Industry 1
Other 1
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