Avoiding Cardiovascular Events Through Combination Therapy in Patients Living With Systolic Hypertension
Terminated
Novartis
Phase 3
2003-10-01
A comparison study of two combination drugs, amlodipine/benazepril and benazepril/HCTZ to
evaluate the effectiveness of the combination on reducing heart disease and death in a high
risk hypertensive population.
Combination of Benazepril Plus Hydrochlorothiazide in Chinese Patients With Mild to Moderate Essential Hypertension
Completed
Novartis
Phase 3
2006-07-01
This study will evaluate efficacy and safety data for benazepril/hydrochlorothiazide in adult
Chinese patients with mild to moderate essential hypertension. Patients whose blood pressure
is not adequately controlled with benazepril monotherapy during a 4 week run-in period will
be randomly allocated to double blind treatment over 8 weeks with either a combination of
benazepril/hydrochlorothiazide per day or continuation of benazepril per day.
Fed Study of Benazepril HCl and Hydrochlorothiazide Tablets 20 mg/25 mg to Lotensin HCT® Tablets 20 mg/25 mg
Completed
Mylan Pharmaceuticals
Phase 1
2002-12-01
The objective of this study was to investigate the bioequivalence of Mylan benazepril HCl and
hydrochlorothiazide 20 mg/25 mg to Novartis Lotensin HCT® 20 mg/25 mg combination tablets
following a single, oral 40 mg/50 mg (2 x 20 mg/25 mg) dose administration under fed
conditions.
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