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Last Updated: April 7, 2025

CLINICAL TRIALS PROFILE FOR BETAINE


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All Clinical Trials for BETAINE

Trial IDTitleStatusSponsorPhaseStart DateSummary
NCT00283387 ↗ Efficacy of Betaine for Reduction of Urine Oxalate in Patients With Type 1 Primary Hyperoxaluria Completed National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) Phase 2 2007-02-01 The aim of this study is to assess the efficacy and safety of betaine in reducing urine oxalate excretion of Type 1 Primary Hyperoxaluria (PHI) patients. Hypothesis: Betaine will effectively reduce urine oxalate excretion in Primary Hyperoxaluria Type I patients.
NCT00226356 ↗ Natural Supplements for Unipolar Depression Completed National Alliance for Research on Schizophrenia and Depression Phase 4 2004-12-01 This study is being conducted to determine the clinical response rate for the regimen of L-methionine, betaine and folate for unipolar depression.
NCT00226356 ↗ Natural Supplements for Unipolar Depression Completed Cambridge Health Alliance Phase 4 2004-12-01 This study is being conducted to determine the clinical response rate for the regimen of L-methionine, betaine and folate for unipolar depression.
NCT00152815 ↗ Non-alcoholic Fatty Liver Disease (NAFLD) in HIV: The Role of Nutritional Interventions Terminated Ontario HIV Treatment Network Phase 2 2003-10-01 The purpose of this study is to evaluate the effect of a one-year nutritional intervention with either betaine or vitamin E supplementation, or a weight reducing diet and exercise program on liver steatosis and steatohepatitis.
NCT00152815 ↗ Non-alcoholic Fatty Liver Disease (NAFLD) in HIV: The Role of Nutritional Interventions Terminated Johane Allard Phase 2 2003-10-01 The purpose of this study is to evaluate the effect of a one-year nutritional intervention with either betaine or vitamin E supplementation, or a weight reducing diet and exercise program on liver steatosis and steatohepatitis.
>Trial ID>Title>Status>Phase>Start Date>Summary
Showing 1 to 5 of 5 entries

Clinical Trial Conditions for BETAINE

Condition Name

3221000.511.522.53HomocystinuriaHealthyChronic Hepatitis CMen Carrying 2 Minor Alleles for Choline Dehydrogenase rs12676[disabled in preview]
Condition Name for BETAINE
Intervention Trials
Homocystinuria 3
Healthy 2
Chronic Hepatitis C 2
Men Carrying 2 Minor Alleles for Choline Dehydrogenase rs12676 1
[disabled in preview] 0
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Condition MeSH

4333000.511.522.533.54HomocystinuriaHepatitis, ChronicHepatitis C, ChronicHepatitis C[disabled in preview]
Condition MeSH for BETAINE
Intervention Trials
Homocystinuria 4
Hepatitis, Chronic 3
Hepatitis C, Chronic 3
Hepatitis C 3
[disabled in preview] 0
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Clinical Trial Locations for BETAINE

Trials by Country

+
Trials by Country for BETAINE
Location Trials
United States 19
Canada 4
Italy 2
India 1
Switzerland 1
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Trials by US State

+
Trials by US State for BETAINE
Location Trials
California 4
Massachusetts 3
North Carolina 2
Nebraska 2
Minnesota 2
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Clinical Trial Progress for BETAINE

Clinical Trial Phase

31.3%12.5%6.2%50.0%012345678Phase 4Phase 3Phase 2/Phase 3[disabled in preview]
Clinical Trial Phase for BETAINE
Clinical Trial Phase Trials
Phase 4 5
Phase 3 2
Phase 2/Phase 3 1
[disabled in preview] 8
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Clinical Trial Status

80.0%8.0%8.0%002468101214161820CompletedTerminatedAvailable[disabled in preview]
Clinical Trial Status for BETAINE
Clinical Trial Phase Trials
Completed 20
Terminated 2
Available 1
[disabled in preview] 2
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Clinical Trial Sponsors for BETAINE

Sponsor Name

trials011223344University of California, San FranciscoMcGill University Health CenterMayo Clinic[disabled in preview]
Sponsor Name for BETAINE
Sponsor Trials
University of California, San Francisco 3
McGill University Health Center 2
Mayo Clinic 2
[disabled in preview] 4
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Sponsor Type

93.9%005101520253035404550OtherIndustryNIH[disabled in preview]
Sponsor Type for BETAINE
Sponsor Trials
Other 46
Industry 2
NIH 1
[disabled in preview] 0
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Betaine: Clinical Trials, Market Analysis, and Projections

Introduction to Betaine

Betaine, a naturally occurring compound found in foods such as beets, spinach, and wheat germ, has garnered significant attention for its diverse health benefits. It supports liver health, promotes cardiovascular health, and enhances athletic performance. Here, we delve into the current clinical trials, market analysis, and future projections for betaine.

Clinical Trials Update

Ongoing and Upcoming Studies

One of the notable clinical trials involving betaine is the study on "Betaine, Exercise Performance, and Gut Permeability." This study, which began in August 2024 and is expected to complete by March 2025, aims to determine if betaine ingestion improves exercise performance, moderates exercise-induced gut permeability, and enhances metabolic recovery.

  • Study Design: The study employs a randomized crossover design with double-blinded, placebo-controlled procedures. Participants are randomized to receive either betaine or a placebo for two weeks before undergoing a 60-km cycling time trial and subsequent recovery sessions[4].

  • Objectives: The primary objectives include assessing the impact of betaine on exercise performance, gut permeability, and metabolic recovery. This study will provide valuable insights into the potential benefits of betaine for athletes and individuals engaging in strenuous physical activities.

Health Benefits of Betaine

Betaine is recognized for its multiple health benefits, which are driving its increasing demand.

  • Liver Health: Betaine supports liver function and is often used in treatments for liver diseases.
  • Cardiovascular Health: It helps in reducing homocysteine levels, which is beneficial for cardiovascular health.
  • Athletic Performance: Betaine is known to improve muscle strength, power, and endurance, making it a popular supplement among athletes[5].

Market Analysis

Current Market Size and Growth

The betaine market has been experiencing steady growth due to increasing demand for nutritional products and dietary supplements.

  • Global Market Size: The global betaine market size was estimated to exceed USD 3.5 billion by 2022 and is projected to grow at a CAGR of over 6% from 2015 to 2022. By 2028, the market is expected to reach $5.25 billion at a CAGR of 6.2%[2][3].

  • Drivers of Growth: Key drivers include the expansion of the nutraceutical market, consumer preference for sustainable products, population growth, urbanization, and climate change impacts. Trends such as biofortification efforts, holistic health approaches, alternative protein sources, and the plant-based revolution are also contributing to the market's growth[3].

Market Segmentation

The betaine market is segmented by product types, applications, and end-users.

  • Applications: Betaine is used in various applications, including feed additives to improve animal metabolism, cosmetics and toiletries due to its high water-holding capacity, and as a dietary supplement for human health benefits[2][5].

  • Geographical Distribution: The market is analyzed across regions such as North America, Europe, Asia Pacific, Middle East, Africa, and LATAM/South and Central America. Each region's market size, CAGR, and market share are detailed to provide a comprehensive geographical understanding[5].

Market Projections

Future Growth Opportunities

The betaine market is expected to continue its growth trajectory driven by several factors.

  • Increasing Demand for Natural Supplements: The rising awareness of betaine's health benefits and the increasing demand for natural and health-focused supplements are key drivers of future growth[5].

  • Innovative Applications: Manufacturers are focusing on optimizing production processes and expanding into new applications, which will further drive the market's growth[5].

  • Sustainable Practices: The emphasis on sustainable practices in the production and sourcing of betaine is expected to positively impact the market[5].

Competitive Analysis

The betaine market is subject to various competitive pressures, including the threat of new entrants, substitutes, and the degree of competition.

  • Porter’s Five Forces Analysis: This analysis evaluates the threat of new entrants, the threat of new substitutes, product differentiation, the degree of competition, and other factors to provide a comprehensive understanding of the market dynamics[5].

  • Leading Companies: Profiles of leading companies in the industry, including their strategies, financials, and products, offer insights into the competitive landscape[5].

Key Takeaways

  • Global Market Size and Growth: The betaine market is projected to reach $5.25 billion by 2028, growing at a CAGR of 6.2%.
  • Health Benefits: Betaine supports liver health, promotes cardiovascular health, and enhances athletic performance.
  • Clinical Trials: Ongoing studies are investigating betaine's impact on exercise performance and gut permeability.
  • Market Drivers: Increasing demand for natural supplements, expansion of the nutraceutical market, and sustainable practices are driving the market's growth.
  • Geographical Distribution: The market is analyzed across multiple regions, providing a detailed geographical understanding.

FAQs

What are the primary health benefits of betaine?

Betaine supports liver health, promotes cardiovascular health, and improves athletic performance by enhancing muscle strength, power, and endurance.

What is the current market size of the betaine market?

The global betaine market size was estimated to exceed USD 3.5 billion by 2022 and is projected to reach $5.25 billion by 2028.

What are the key drivers of the betaine market growth?

Key drivers include the expansion of the nutraceutical market, consumer preference for sustainable products, population growth, urbanization, and climate change impacts.

What are the main applications of betaine?

Betaine is used in feed additives, cosmetics and toiletries, and as a dietary supplement for human health benefits.

Are there any ongoing clinical trials involving betaine?

Yes, a clinical trial is ongoing to determine the impact of betaine on exercise performance, gut permeability, and metabolic recovery.

Sources

  1. Grand View Research: Global Betaine Market Size, Share, Trends | Industry Report, 2022.
  2. The Business Research Company: Betaine Global Market Report 2024.
  3. Research and Markets: Betaine Market Forecast (2025-2032): Industry Size, Market Share.
  4. CenterWatch: Betaine, Exercise Performance, and Gut Permeability | Clinical Trials.
  5. Research and Markets: Betaine Market Forecast (2025-2032): Industry Size, Market Share.

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