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Last Updated: November 4, 2024

CLINICAL TRIALS PROFILE FOR CEFTRIAXONE SODIUM; LIDOCAINE


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All Clinical Trials for CEFTRIAXONE SODIUM; LIDOCAINE

Trial ID Title Status Sponsor Phase Start Date Summary
NCT03587441 ↗ Intrathecal Neostigmine for Prevention of PDPH Completed Fayoum University Hospital Phase 4 2018-08-04 Neuraxial blocks continue to be the cornerstone of anesthesia and postoperative analgesia for normal vaginal delivery and elective caesarean section due to its approved safety and efficiency for decades. Post-dural puncture headache (PDPH) is still one of the most common complications of neuraxial anesthetic techniques. The headache could be severe and limit the activities of the new mother to care for her baby, prolong hospital stay. PDPH is defined as a headache that develops within five days of dural puncture and can't be attributed to any other types of headache and mostly is postural in character. Neostigmine methylsulfate is a synthetic carbamic acid ester which reversibly inhibits the enzyme Acetylcholine esterase (AChE) that makes more Acetylcholine molecules available at cholinergic receptors. Neostigmine is used in anesthesia mainly as a reversal for non-depolarizing neuromuscular agents. Intrathecal (IT) neostigmine was tried as an adjuvant to local anesthetics in IT block for elective cesarean sections to decrease local anesthetic consumption and to prolong postoperative analgesia. Side effects of IT neostigmine are dose-dependent with doses more than 25 µg especially nausea and vomiting and could be decreased by increasing the baricities of the local anesthetic solutions and by early head up position after IT injection. However, its effect on PDPH was not investigated before in literature. Parturients will be randomly assigned into one of two groups: the intervention group will receive 20 µg with IT Bupivacaine and the control group will receive an equivalent volume of dextrose 5% with the IT Bupivacaine. The objective of the current study is to evaluate the efficacy and safety of IT neostigmine as an adjuvant to bupivacaine in reducing the incidence and severity of post-dural puncture headache in parturients scheduled for an elective cesarean section.
NCT03853096 ↗ P.Acnes Colony Count Following Subdermal Cefazolin Unknown status University of British Columbia Early Phase 1 2019-04-01 The specific outcome is to determine whether the colony count of Propionibacterium acnes, one of the commonest causes of shoulder infection and not eradicated by conventional forms of surgical preparatory solutions and antibiotics, in a shoulder surgical wound will be altered by the use of subdermal cefazolin.
>Trial ID >Title >Status >Phase >Start Date >Summary

Clinical Trial Conditions for CEFTRIAXONE SODIUM; LIDOCAINE

Condition Name

Condition Name for CEFTRIAXONE SODIUM; LIDOCAINE
Intervention Trials
Microbial Colonization 1
Post-Dural Puncture Headache 1
Surgical Site Infection 1
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Condition MeSH

Condition MeSH for CEFTRIAXONE SODIUM; LIDOCAINE
Intervention Trials
Infection 1
Communicable Diseases 1
Post-Dural Puncture Headache 1
Headache 1
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Clinical Trial Locations for CEFTRIAXONE SODIUM; LIDOCAINE

Trials by Country

Trials by Country for CEFTRIAXONE SODIUM; LIDOCAINE
Location Trials
Egypt 1
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Clinical Trial Progress for CEFTRIAXONE SODIUM; LIDOCAINE

Clinical Trial Phase

Clinical Trial Phase for CEFTRIAXONE SODIUM; LIDOCAINE
Clinical Trial Phase Trials
Phase 4 1
Early Phase 1 1
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Clinical Trial Status

Clinical Trial Status for CEFTRIAXONE SODIUM; LIDOCAINE
Clinical Trial Phase Trials
Completed 1
Unknown status 1
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Clinical Trial Sponsors for CEFTRIAXONE SODIUM; LIDOCAINE

Sponsor Name

Sponsor Name for CEFTRIAXONE SODIUM; LIDOCAINE
Sponsor Trials
Fayoum University Hospital 1
University of British Columbia 1
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Sponsor Type

Sponsor Type for CEFTRIAXONE SODIUM; LIDOCAINE
Sponsor Trials
Other 2
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