CLINICAL TRIALS PROFILE FOR CHLOROPROCAINE HYDROCHLORIDE
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All Clinical Trials for CHLOROPROCAINE HYDROCHLORIDE
| Trial ID | Title | Status | Sponsor | Phase | Start Date | Summary |
|---|---|---|---|---|---|---|
| NCT00487084 ↗ | Effect of Timing on Efficacy of Morphine Analgesia After 2-chloroprocaine Anesthesia | Completed | Northwestern University | N/A | 2004-08-01 | Epidural chloroprocaine is often used in obstetrical anesthesia because of its fast onset and short duration. These properties make it an ideal drug to use for epidural anesthesia in patients undergoing postpartum tubal ligation. When epidural morphine is given after chloroprocaine, there is a decreased efficacy of analgesia as compared to lidocaine (1). Several studies have hypothesized a specific opioid receptor mediated antagonism of chloroprocaine (2,3). Karambelkar raised the question whether this decreased efficacy is due to a disparity between the time the chloroprocaine anesthesia resolves and the onset of epidural morphine analgesia, resulting in a time window of pain (2). The duration of action of epidural 2-CP anesthesia is 30-45 minutes and the onset of epidural morphine analgesia is 60-70 minutes, therefore the regression of sensory blockade before the onset of the morphine analgesia could result in a window of pain (2). Hess and colleagues studied epidural morphine analgesia and women who had a Cesarean delivery under spinal bupivacaine anesthesia (3). Subjects were randomized to receive epidural 2-CP and morphine or epidural saline and morphine. There was no difference in postoperative analgesia between the two groups (3 and personal communication, Dr. Philip Hess). A literature search cross referencing epidural chloroprocaine, using Pub Med, did not produce any articles comparing epidural morphine given before the procedure (in an attempt to time the onset of analgesia with the resolution of chloroprocaine anesthesia) to the standard administration time after the procedure. |
| NCT00845962 ↗ | A Comparison of Bupivacaine and 2-chloroprocaine for Spinal Anesthesia | Completed | Centre hospitalier de l'Université de Montréal (CHUM) | N/A | 2009-02-01 | The purpose of this study is to compare the efficacity and the readiness for discharge between two local anesthetics, bupivacaine and 2-chloroprocaine, used for spinal anesthesia. |
| NCT00845962 ↗ | A Comparison of Bupivacaine and 2-chloroprocaine for Spinal Anesthesia | Completed | Université de Montréal | N/A | 2009-02-01 | The purpose of this study is to compare the efficacity and the readiness for discharge between two local anesthetics, bupivacaine and 2-chloroprocaine, used for spinal anesthesia. |
| NCT01719237 ↗ | Trial Comparing the Onset and Duration of Ultrasound Guided Supraclavicular Nerve Blocks Using Ropivacaine Versus Ropivacaine-Chloroprocaine Mixture | Completed | VA Palo Alto Health Care System | Phase 4 | 2009-08-01 | A double blinded randomized controlled trial comparing the onset and duration of the Onset and Duration of Ultrasound Guided Supraclavicular Nerve Blocks Using a long acting local anesthestic (Ropivacaine) with a mixture of a long and short acting local anesthestic (Ropivacaine-Chloroprocaine Mixture). |
| >Trial ID | >Title | >Status | >Sponsor | >Phase | >Start Date | >Summary |
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