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Last Updated: November 2, 2024

CLINICAL TRIALS PROFILE FOR CHLOROQUINE PHOSPHATE


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All Clinical Trials for CHLOROQUINE PHOSPHATE

Trial ID Title Status Sponsor Phase Start Date Summary
NCT00140517 ↗ Relationships Between the Use of Antimalarial Drugs in Pregnancy and Plasmodium Falciparum Resistance Completed DBL -Institute for Health Research and Development N/A 2002-10-01 Plasmodium falciparum resistance to chloroquine (CQ) and sulfadoxine-pyrimethamine (SP) continue to spread, impeding control of this important disease. CQ and SP are still the most commonly used antimalarial drugs for malaria prevention during pregnancy and might be made less effective by resistance. However, the treatment and prophylaxis regimens used may also create conditions for selecting resistant malaria parasite strains. A better understanding of the relationships between chemoprophylaxis regimens and resistance would be helpful to improve chemoprophylaxis of malaria in pregnancy. This work aims to improve the use of chemoprophylaxis in pregnancy by determining whether there is a relationship between the use of standard prophylactic regimens with CQ and SP and the occurrence of P. falciparum resistant strains in pregnant women. The study consists of 2 parts. The first part is a randomized trial comparing 3 chemoprophylactic treatment groups: - weekly CQ after initial presumptive CQ treatment, - CQ intermittent presumptive treatment given as a standard dose at 2nd and 3rd trimester, respectively and SP intermittent presumptive treatment given as a single dose at 2nd and 3rd trimester, respectively. These treatment groups will also be compared to a group of women delivering at the same health centre but who have not been participating in the study. The second part will be a clinical trial for assessment of clinical and parasitological efficacy of CQ and SP treatment in pregnant women presenting with uncomplicated malaria attacks. The study will be conducted from October 2002 to March 2005 in a health centre of Ouagadougou, Burkina Faso where malaria transmission is seasonal and resistance to CQ and SP is low.
NCT00140517 ↗ Relationships Between the Use of Antimalarial Drugs in Pregnancy and Plasmodium Falciparum Resistance Completed Gates Malaria Partnership N/A 2002-10-01 Plasmodium falciparum resistance to chloroquine (CQ) and sulfadoxine-pyrimethamine (SP) continue to spread, impeding control of this important disease. CQ and SP are still the most commonly used antimalarial drugs for malaria prevention during pregnancy and might be made less effective by resistance. However, the treatment and prophylaxis regimens used may also create conditions for selecting resistant malaria parasite strains. A better understanding of the relationships between chemoprophylaxis regimens and resistance would be helpful to improve chemoprophylaxis of malaria in pregnancy. This work aims to improve the use of chemoprophylaxis in pregnancy by determining whether there is a relationship between the use of standard prophylactic regimens with CQ and SP and the occurrence of P. falciparum resistant strains in pregnant women. The study consists of 2 parts. The first part is a randomized trial comparing 3 chemoprophylactic treatment groups: - weekly CQ after initial presumptive CQ treatment, - CQ intermittent presumptive treatment given as a standard dose at 2nd and 3rd trimester, respectively and SP intermittent presumptive treatment given as a single dose at 2nd and 3rd trimester, respectively. These treatment groups will also be compared to a group of women delivering at the same health centre but who have not been participating in the study. The second part will be a clinical trial for assessment of clinical and parasitological efficacy of CQ and SP treatment in pregnant women presenting with uncomplicated malaria attacks. The study will be conducted from October 2002 to March 2005 in a health centre of Ouagadougou, Burkina Faso where malaria transmission is seasonal and resistance to CQ and SP is low.
NCT00140517 ↗ Relationships Between the Use of Antimalarial Drugs in Pregnancy and Plasmodium Falciparum Resistance Completed London School of Hygiene and Tropical Medicine N/A 2002-10-01 Plasmodium falciparum resistance to chloroquine (CQ) and sulfadoxine-pyrimethamine (SP) continue to spread, impeding control of this important disease. CQ and SP are still the most commonly used antimalarial drugs for malaria prevention during pregnancy and might be made less effective by resistance. However, the treatment and prophylaxis regimens used may also create conditions for selecting resistant malaria parasite strains. A better understanding of the relationships between chemoprophylaxis regimens and resistance would be helpful to improve chemoprophylaxis of malaria in pregnancy. This work aims to improve the use of chemoprophylaxis in pregnancy by determining whether there is a relationship between the use of standard prophylactic regimens with CQ and SP and the occurrence of P. falciparum resistant strains in pregnant women. The study consists of 2 parts. The first part is a randomized trial comparing 3 chemoprophylactic treatment groups: - weekly CQ after initial presumptive CQ treatment, - CQ intermittent presumptive treatment given as a standard dose at 2nd and 3rd trimester, respectively and SP intermittent presumptive treatment given as a single dose at 2nd and 3rd trimester, respectively. These treatment groups will also be compared to a group of women delivering at the same health centre but who have not been participating in the study. The second part will be a clinical trial for assessment of clinical and parasitological efficacy of CQ and SP treatment in pregnant women presenting with uncomplicated malaria attacks. The study will be conducted from October 2002 to March 2005 in a health centre of Ouagadougou, Burkina Faso where malaria transmission is seasonal and resistance to CQ and SP is low.
>Trial ID >Title >Status >Phase >Start Date >Summary

Clinical Trial Conditions for CHLOROQUINE PHOSPHATE

Condition Name

Condition Name for CHLOROQUINE PHOSPHATE
Intervention Trials
COVID-19 12
Malaria 10
Vivax Malaria 4
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Condition MeSH

Condition MeSH for CHLOROQUINE PHOSPHATE
Intervention Trials
Malaria 18
COVID-19 16
Malaria, Vivax 10
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Clinical Trial Locations for CHLOROQUINE PHOSPHATE

Trials by Country

Trials by Country for CHLOROQUINE PHOSPHATE
Location Trials
Indonesia 11
United States 9
Thailand 8
Ethiopia 5
Brazil 5
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Trials by US State

Trials by US State for CHLOROQUINE PHOSPHATE
Location Trials
New York 2
Arizona 1
Connecticut 1
Virginia 1
Maryland 1
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Clinical Trial Progress for CHLOROQUINE PHOSPHATE

Clinical Trial Phase

Clinical Trial Phase for CHLOROQUINE PHOSPHATE
Clinical Trial Phase Trials
Phase 4 10
Phase 3 11
Phase 2/Phase 3 4
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Clinical Trial Status

Clinical Trial Status for CHLOROQUINE PHOSPHATE
Clinical Trial Phase Trials
Completed 27
Not yet recruiting 7
Terminated 4
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Clinical Trial Sponsors for CHLOROQUINE PHOSPHATE

Sponsor Name

Sponsor Name for CHLOROQUINE PHOSPHATE
Sponsor Trials
University of Oxford 7
Shahid Beheshti University of Medical Sciences 4
Medicines for Malaria Venture 4
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Sponsor Type

Sponsor Type for CHLOROQUINE PHOSPHATE
Sponsor Trials
Other 121
Industry 9
U.S. Fed 3
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