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Last Updated: November 22, 2024

CLINICAL TRIALS PROFILE FOR CLOFIBRATE


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All Clinical Trials for CLOFIBRATE

Trial ID Title Status Sponsor Phase Start Date Summary
NCT00000482 ↗ Coronary Drug Project Completed National Heart, Lung, and Blood Institute (NHLBI) Phase 3 1965-04-01 To determine whether regular administration of lipid modifying drugs (clofibrate, nicotinic acid, estrogen, dextrothyroxine) to men with a documented myocardial infarction would result in significant reduction in total mortality over a five year period. Secondarily, to determine whether the degree to which these drugs changed serum lipids was correlated with any effect on mortality and morbidity rates; to gain further information on the long-term prognosis of myocardial infarction (by studying the control group as intensively as the treatment group); to acquire further experience and knowledge concerning the techniques and methodology of long-term clinical trials; to determine, in a substudy, the effectiveness of aspirin, a platelet inhibitor, in reducing recurrences of myocardial infarction.
NCT00000483 ↗ Coronary Drug Project Mortality Surveillance Completed National Heart, Lung, and Blood Institute (NHLBI) N/A 1981-06-01 To determine whether there were any long term sequelae of the drugs used in the Coronary Drug Project (estrogens, dextrothyroxine, nicotinic acid, clofibrate).
NCT00238004 ↗ The Low HDL On Six Weeks Statin Therapy (LOW) Study Unknown status Craigavon Area Hospital Phase 4 2005-11-01 Abnormal blood cholesterol levels increase the risk of developing, or dying from heart disease. It is well recognised that if "harmful" LDL cholesterol is high, and "protective" HDL cholesterol is low, this risk is increased. Drugs called statins are routinely used in patients with heart disease, are well tolerated, and decrease the harmful LDL cholesterol levels. However, statins only increase protective HDL cholesterol to a small extent. Some patients may thus benefit from additional medication to increase protective HDL-cholesterol further. One of the most effective drugs which can do this is nicotinic acid. This drug is well established having been available for over 30 years. Previous use has been limited by facial flushing in a large percentage of patients receiving the drug. However a new formulation called Niaspan is now available which is associated with much less flushing. Although many patients will have transient flushing, it is estimated that only 1 patient out of every 20 receiving the drug will have to discontinue treatment. We therefore propose, in patients with coronary artery disease and low HDL cholesterol despite being on a statin, to study the effect of Niaspan on HDL cholesterol and other lipid parameters, and to assess its tolerability.
>Trial ID >Title >Status >Phase >Start Date >Summary

Clinical Trial Conditions for CLOFIBRATE

Condition Name

Condition Name for CLOFIBRATE
Intervention Trials
Heart Diseases 2
Myocardial Infarction 2
Cardiovascular Diseases 2
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Condition MeSH

Condition MeSH for CLOFIBRATE
Intervention Trials
Coronary Artery Disease 3
Myocardial Ischemia 3
Heart Diseases 2
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Clinical Trial Locations for CLOFIBRATE

Trials by Country

Trials by Country for CLOFIBRATE
Location Trials
Brazil 1
United Kingdom 1
Canada 1
Denmark 1
Mexico 1
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Trials by US State

Trials by US State for CLOFIBRATE
Location Trials
Maryland 1
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Clinical Trial Progress for CLOFIBRATE

Clinical Trial Phase

Clinical Trial Phase for CLOFIBRATE
Clinical Trial Phase Trials
Phase 4 2
Phase 3 2
Phase 2 2
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Clinical Trial Status

Clinical Trial Status for CLOFIBRATE
Clinical Trial Phase Trials
Completed 5
Unknown status 2
Terminated 1
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Clinical Trial Sponsors for CLOFIBRATE

Sponsor Name

Sponsor Name for CLOFIBRATE
Sponsor Trials
National Heart, Lung, and Blood Institute (NHLBI) 2
Fundação de Amparo à Pesquisa do Estado de São Paulo 1
Federal University of São Paulo 1
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Sponsor Type

Sponsor Type for CLOFIBRATE
Sponsor Trials
Other 8
NIH 2
Industry 1
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