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Last Updated: November 2, 2024

CLINICAL TRIALS PROFILE FOR CLOROTEKAL


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All Clinical Trials for CLOROTEKAL

Trial ID Title Status Sponsor Phase Start Date Summary
NCT03967288 ↗ Comparison of Clorotekal and Bupivacaine for Short Obstetric Surgery Recruiting B. Braun Medical Inc. Phase 4 2019-10-24 The following obstetric procedures are commonly performed with spinal anesthesia on labor and delivery: bilateral tubal ligation, external cephalic version, cerclage insertion, cerclage removal, minimally invasive fetal surgery, and evacuation of retained products of conception. Bupivacaine is currently the standard spinal medication for these procedures because of its long history of safe use, its low incidence of transient neurologic symptoms, and its ability to provide a dependable, dense block with a high degree of maternal satisfaction. While bupivacaine has the aforementioned advantages, it unfortunately has a long duration of action, up to 240-380 minutes, which far exceeds the time necessary to complete most obstetric procedures. Clorotekal®, the first Food and Drug Administration approved chloroprocaine solution created for spinal injection, is a potential alternative. When compared with bupivacaine spinals, chloroprocaine spinals have been shown to facilitate clinically significant shorter times to resolution of motor and sensory block, first ambulation, micturition, and discharge readiness. The objective of this study is to determine if a strategy of spinal anesthesia with chloroprocaine will reduce the duration of motor block, compared with equivalent block with hyperbaric bupivacaine..
NCT03967288 ↗ Comparison of Clorotekal and Bupivacaine for Short Obstetric Surgery Recruiting Oregon Health and Science University Phase 4 2019-10-24 The following obstetric procedures are commonly performed with spinal anesthesia on labor and delivery: bilateral tubal ligation, external cephalic version, cerclage insertion, cerclage removal, minimally invasive fetal surgery, and evacuation of retained products of conception. Bupivacaine is currently the standard spinal medication for these procedures because of its long history of safe use, its low incidence of transient neurologic symptoms, and its ability to provide a dependable, dense block with a high degree of maternal satisfaction. While bupivacaine has the aforementioned advantages, it unfortunately has a long duration of action, up to 240-380 minutes, which far exceeds the time necessary to complete most obstetric procedures. Clorotekal®, the first Food and Drug Administration approved chloroprocaine solution created for spinal injection, is a potential alternative. When compared with bupivacaine spinals, chloroprocaine spinals have been shown to facilitate clinically significant shorter times to resolution of motor and sensory block, first ambulation, micturition, and discharge readiness. The objective of this study is to determine if a strategy of spinal anesthesia with chloroprocaine will reduce the duration of motor block, compared with equivalent block with hyperbaric bupivacaine..
NCT03993314 ↗ Optimizing Anesthesia for Post Partum Tubal Ligations Terminated University of Alabama at Birmingham Phase 2 2019-08-13 In this study, the investigators will compare CLOROTEKAL® (1% spinal chloroprocaine) to low-dose isobaric bupivacaine using the epidural volume extension (EVE) technique in patients undergoing post-partum tubal ligation (PPBTL). This will be a randomized, double-blinded study. Patients scheduled for PPBTL at the Women and Infants Center (WIC) will be eligible for enrollment in this study. Outcomes measured will include: ability to achieve an adequate level required for surgery (T6), rate of epidural activation, and duration of the block. The investigators hope to determine the usefulness of each drug using the EVE technique in the setting of PPBTL.
>Trial ID >Title >Status >Phase >Start Date >Summary

Clinical Trial Conditions for CLOROTEKAL

Condition Name

Condition Name for CLOROTEKAL
Intervention Trials
Anesthesia, Spinal 1
Pregnancy Related 1
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Condition MeSH

Condition MeSH for CLOROTEKAL
Intervention Trials
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Clinical Trial Locations for CLOROTEKAL

Trials by Country

Trials by Country for CLOROTEKAL
Location Trials
United States 2
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Trials by US State

Trials by US State for CLOROTEKAL
Location Trials
Alabama 1
Oregon 1
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Clinical Trial Progress for CLOROTEKAL

Clinical Trial Phase

Clinical Trial Phase for CLOROTEKAL
Clinical Trial Phase Trials
Phase 4 1
Phase 2 1
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Clinical Trial Status

Clinical Trial Status for CLOROTEKAL
Clinical Trial Phase Trials
Terminated 1
Recruiting 1
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Clinical Trial Sponsors for CLOROTEKAL

Sponsor Name

Sponsor Name for CLOROTEKAL
Sponsor Trials
Oregon Health and Science University 1
University of Alabama at Birmingham 1
B. Braun Medical Inc. 1
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Sponsor Type

Sponsor Type for CLOROTEKAL
Sponsor Trials
Other 2
Industry 1
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