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Last Updated: November 7, 2024

CLINICAL TRIALS PROFILE FOR COBICISTAT; DARUNAVIR


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All Clinical Trials for COBICISTAT; DARUNAVIR

Trial ID Title Status Sponsor Phase Start Date Summary
NCT00855335 ↗ A Single-arm, Open-label, Study to Assess the Pharmacokinetics of Darunavir and Ritonavir, Darunavir and Cobicistat, Etravirine, and Rilpivirine in HIV-1 Infected Pregnant Women Completed Janssen Scientific Affairs, LLC Phase 3 2009-04-09 The purpose of this study is to study how changes in the body during pregnancy influence the blood levels of TMC114 (darunavir) and ritonavir taken together, darunavir and cobicistat taken as a fixed-dose combination, TMC125 (etravirine) taken alone or with darunavir and ritonavir or rilpivirine in patients with human immunodeficiency virus-1 (HIV-1). This study will examine how these drugs are absorbed in the body, how they are distributed within the body and how they are removed from the body over time. Any pregnant woman who is currently receiving darunavir with ritonavir, darunavir with cobicistat, etravirine or rilpivirine for HIV-1, and who meets the eligibility criteria for the study, will be allowed to enroll. Patients must be willing to remain on study medication during the course of their pregnancy, and 12 weeks postpartum. The information collected may help answer questions about how to best prescribe these three drugs for pregnant women.
NCT01440569 ↗ Safety and Efficacy of Cobicistat-boosted Darunavir in HIV Infected Adults Completed Janssen Research & Development, LLC Phase 3 2011-09-01 This study is to evaluate the safety and tolerability of cobicistat-boosted darunavir plus two fully active nucleoside analogue reverse transcriptase inhibitors in HIV 1 infected, antiretroviral treatment-naive and treatment-experienced adults with no darunavir (DRV) resistance-associated mutations. After the Week 48 Visit, participants will be given the option to participate in an open-label rollover phase to receive cobicistat and attend visits every 12 weeks until it becomes commercially available, or until Gilead Sciences elects to terminate development of cobicistat.
NCT01440569 ↗ Safety and Efficacy of Cobicistat-boosted Darunavir in HIV Infected Adults Completed Gilead Sciences Phase 3 2011-09-01 This study is to evaluate the safety and tolerability of cobicistat-boosted darunavir plus two fully active nucleoside analogue reverse transcriptase inhibitors in HIV 1 infected, antiretroviral treatment-naive and treatment-experienced adults with no darunavir (DRV) resistance-associated mutations. After the Week 48 Visit, participants will be given the option to participate in an open-label rollover phase to receive cobicistat and attend visits every 12 weeks until it becomes commercially available, or until Gilead Sciences elects to terminate development of cobicistat.
NCT01565850 ↗ D/C/F/TAF Versus COBI-boosted DRV Plus FTC/TDF in HIV-1 Infected, Antiretroviral Treatment Naive Adults Completed Gilead Sciences Phase 2 2012-04-01 This study is to evaluate the safety and efficacy darunavir/cobicistat/emtricitabine/tenofovir alafenamide (D/C/F/TAF) fixed dose combination (FDC) tablet versus darunavir (DRV)+cobicistat (COBI)+emtricitabine (FTC)/tenofovir disoproxil fumarate (TDF) in HIV-1 infected, antiretroviral treatment-naive adults as determined by the achievement of HIV-1 RNA < 50 copies/mL at Week 24.
NCT01619527 ↗ A Study to Assess the Bioequivalence of Darunavir When Co-Administrated With Cobicistat Under Fed and Fasted Conditions Completed Janssen R&D Ireland Phase 1 2012-04-01 The purpose of this study is to evaluate the single-dose pharmacokinetics and bioequivalence of darunavir 800 mg when administered as a fixed dose combination relative to 2 x 400 mg tablets of the commercial tablet formulation, in the presence of 150 mg cobicistat, (under fed and fasted conditions) in healthy participants.
>Trial ID >Title >Status >Phase >Start Date >Summary

Clinical Trial Conditions for COBICISTAT; DARUNAVIR

Condition Name

Condition Name for COBICISTAT; DARUNAVIR
Intervention Trials
HIV Infections 9
Healthy 9
HIV 5
HIV-1 5
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Condition MeSH

Condition MeSH for COBICISTAT; DARUNAVIR
Intervention Trials
HIV Infections 20
Acquired Immunodeficiency Syndrome 12
Immunologic Deficiency Syndromes 8
Infections 5
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Clinical Trial Locations for COBICISTAT; DARUNAVIR

Trials by Country

Trials by Country for COBICISTAT; DARUNAVIR
Location Trials
United States 169
Spain 17
Canada 12
Belgium 9
United Kingdom 6
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Trials by US State

Trials by US State for COBICISTAT; DARUNAVIR
Location Trials
Texas 14
Georgia 12
Florida 9
California 9
District of Columbia 8
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Clinical Trial Progress for COBICISTAT; DARUNAVIR

Clinical Trial Phase

Clinical Trial Phase for COBICISTAT; DARUNAVIR
Clinical Trial Phase Trials
Phase 4 16
Phase 3 11
Phase 2/Phase 3 3
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Clinical Trial Status

Clinical Trial Status for COBICISTAT; DARUNAVIR
Clinical Trial Phase Trials
Completed 33
Not yet recruiting 6
Recruiting 5
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Clinical Trial Sponsors for COBICISTAT; DARUNAVIR

Sponsor Name

Sponsor Name for COBICISTAT; DARUNAVIR
Sponsor Trials
Janssen Scientific Affairs, LLC 8
Janssen Research & Development, LLC 7
Gilead Sciences 7
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Sponsor Type

Sponsor Type for COBICISTAT; DARUNAVIR
Sponsor Trials
Industry 44
Other 44
NIH 2
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