This study will randomize 30 septic shock patients to receive either a single 5 gram dose of
IV vitamin B12 (Cyanokit® Meridian Medical Technologies, Columbia, MD) versus placebo in
addition to standard of care to reduce vasopressor dose at 3 hours.
Methylene Blue vs Cyanokit for Intraoperative Vasoplegic Syndrome in Liver Transplant Patients
Recruiting
Mayo Clinic
Phase 4
2021-12-30
This study will evaluate if Hydroxocobalamin may be a new and possibly superior treatment for
refractory vasoplegic syndrome during liver transplant surgery.
Prophylactic Use of Hydroxycobolamin in Vasoplegic Syndrome in Adult Patients Undergoing Cardiopulmonary Bypass
Completed
Ain Shams University
Phase 2/Phase 3
2019-08-28
Several studies have described the use of alternative drugs as methylene blue (MB) (3) other
than the standard limited options of the use of vasopressors and systemic corticosteroids (4)
especially in the face of increasing incidence of vasoplegic syndrome. Hydroxycobolamin (HCO)
has been used for treating cyanide poisoning for more than 40 years. Persistant and
significant hypertension occurred as a result of the ability of (HCO) to bind nitric oxide
(NO) to form nitrocobalamin.
In this prospective randomized controlled trial, we hypothesized that the prophylactic use of
HCO in high risk patients after CPB may decrease the incidence of vasoplegia.
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