Decitabine and Valproic Acid in Treating Patients With Refractory or Relapsed Acute Myeloid Leukemia or Previously Treated Chronic Lymphocytic Leukemia or Small Lymphocytic Lymphoma
Completed
National Cancer Institute (NCI)
Phase 1
2004-02-01
This phase I trial is studying the side effects and best dose of decitabine and valproic acid
in treating patients with refractory or relapsed acute myeloid leukemia or previously treated
chronic lymphocytic leukemia or small lymphocytic leukemia. Drugs used in chemotherapy, such
as decitabine, work in different ways to stop cancer cells from dividing so they stop growing
or die. Valproic acid may stop the growth of cancer cells by blocking the enzymes necessary
for their growth. Combining decitabine with valproic acid may kill more cancer cells.
Decitabine and Valproic Acid in Treating Patients With Non-Small Cell Lung Cancer
Completed
National Cancer Institute (NCI)
Phase 1
2004-04-01
This phase I trial is studying the side effects and best dose of decitabine and valproic acid
in treating patients with non-small cell lung cancer. Drugs used in chemotherapy, such as
decitabine and valproic acid, work in different ways to stop tumor cells from dividing so
they stop growing or die. Combining more than one drug may kill more tumor cells.
Decitabine With or Without Valproic Acid in Treating Patients With Relapsed or Refractory Non-Hodgkin's Lymphoma
Completed
National Cancer Institute (NCI)
Phase 1
2006-03-01
Drugs used in chemotherapy, such as decitabine, work in different ways to stop the growth of
cancer cells, either by killing the cells or by stopping them from dividing. Valproic acid
may stop the growth of cancer cells by blocking some of the enzymes needed for cell growth.
Giving decitabine together with valproic acid may be an effective treatment for non-Hodgkin's
lymphoma. This phase I trial is studying the side effects and best dose of decitabine and
valproic acid in treating patients with relapsed or refractory aggressive B-cell
non-Hodgkin's lymphoma.
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