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Last Updated: November 5, 2024

CLINICAL TRIALS PROFILE FOR DESOXYN


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All Clinical Trials for DESOXYN

Trial ID Title Status Sponsor Phase Start Date Summary
NCT01967381 ↗ Targeting GABA and Opioid Systems for a Pharmacotherapy for Methamphetamine Abuse Completed National Institute on Drug Abuse (NIDA) Early Phase 1 2013-10-01 The research proposed in this application will determine the initial efficacy, safety and tolerability of a novel drug combination, oxazepam (Serax®) and naltrexone (Revia®), as a pharmacotherapy for methamphetamine (Desoxyn®) dependence. A rigorous, inpatient human laboratory study will be conducted. The proposed study is innovative and important because it will provide the impetus for the conduct of double blind, placebo-controlled trials to further demonstrate the efficacy of combined oxazepam and naltrexone for managing methamphetamine dependence.
NCT01967381 ↗ Targeting GABA and Opioid Systems for a Pharmacotherapy for Methamphetamine Abuse Completed University of Kentucky Early Phase 1 2013-10-01 The research proposed in this application will determine the initial efficacy, safety and tolerability of a novel drug combination, oxazepam (Serax®) and naltrexone (Revia®), as a pharmacotherapy for methamphetamine (Desoxyn®) dependence. A rigorous, inpatient human laboratory study will be conducted. The proposed study is innovative and important because it will provide the impetus for the conduct of double blind, placebo-controlled trials to further demonstrate the efficacy of combined oxazepam and naltrexone for managing methamphetamine dependence.
NCT02058966 ↗ Pilot Study of Entacapone for Methamphetamine Abuse Completed Portland VA Medical Center Early Phase 1 2014-06-01 Addiction to methamphetamine is a serious health problem. There are no medications that a doctor can give someone to help them stop using methamphetamine. Entacapone (Comtan©) is a medication that could help people addicted to methamphetamine. This study will see how entacapone works in healthy people who are given methamphetamine. We think that the study drug will be well tolerated, and that it will prevent some of the effects of methamphetamine that make it so addictive. We also want to see how differences in people's genes may cause differences in the ways the study drug and methamphetamine work for them. The study has six total visits. The first visit is for screening. Tests and procedures will make sure it is safe for subjects to participate. The second visit is a familiarization day. Subjects will receive methamphetamine, but no entacapone. This is done to make sure they can tolerate the drug and recognize its effects before being given a second drug on the same day. Subjects will take surveys and computer tests to see how the medications change mood, thinking, and liking the drug. The final four visits are the actual study days. Subjects will be randomly assigned (like the flip of a coin) to the different ways to get either 1) study medication or placebo (placebo contains no active study medication) and then 2) methamphetamine or placebo. Subjects will be in all four groups during the study, which means that each day a subject will get a different group.
>Trial ID >Title >Status >Phase >Start Date >Summary

Clinical Trial Conditions for DESOXYN

Condition Name

Condition Name for DESOXYN
Intervention Trials
Methamphetamine Dependence 2
Methamphetamine-dependence 2
Methamphetamine Abuse 1
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Condition MeSH

Condition MeSH for DESOXYN
Intervention Trials
HIV Infections 1
Acquired Immunodeficiency Syndrome 1
Substance-Related Disorders 1
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Clinical Trial Locations for DESOXYN

Trials by Country

Trials by Country for DESOXYN
Location Trials
United States 4
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Trials by US State

Trials by US State for DESOXYN
Location Trials
Oregon 2
California 1
Kentucky 1
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Clinical Trial Progress for DESOXYN

Clinical Trial Phase

Clinical Trial Phase for DESOXYN
Clinical Trial Phase Trials
Phase 4 2
N/A 1
Early Phase 1 2
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Clinical Trial Status

Clinical Trial Status for DESOXYN
Clinical Trial Phase Trials
Completed 3
Recruiting 2
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Clinical Trial Sponsors for DESOXYN

Sponsor Name

Sponsor Name for DESOXYN
Sponsor Trials
Portland VA Medical Center 2
Oregon Health and Science University 2
National Institute on Drug Abuse (NIDA) 2
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Sponsor Type

Sponsor Type for DESOXYN
Sponsor Trials
Other 5
U.S. Fed 2
NIH 2
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