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Last Updated: December 23, 2024

CLINICAL TRIALS PROFILE FOR DEXAMETHASONE SODIUM PHOSPHATE; LIDOCAINE HYDROCHLORIDE


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All Clinical Trials for DEXAMETHASONE SODIUM PHOSPHATE; LIDOCAINE HYDROCHLORIDE

Trial ID Title Status Sponsor Phase Start Date Summary
NCT01372904 ↗ Prevention of Cisplatin-Induced Hearing Loss by Intratympanic Dexamethasone Treatment Completed Meir Medical Center Phase 4 2011-06-01 Cisplatin is a widely used chemotherapeutic agent for the treatment of various malignant neoplasms, including testicular, ovarian, bladder, cervix uteri, head and neck and lung cancers. One of the common side-effects of this drug is bilateral, symmetric, progressive and usually irreversible sensorineural hearing loss. Cisplatin induces cochlear toxicity by the production of reactive oxygen species (ROS). Dexamethasone treatment is currently practiced for various pathologies afflicting the inner ear. The positive effect of Dexamethasone is attributed to it's anti ROS activity and it's capability to up-regulate cochlear anti ROS enzymes. In order to reach higher inner ear concentration of the drug while avoiding it's undesirable systemic side-effects, Intratympanic (IT) delivery of Dexamethasone became vastly used in the last decades for the treatment of sudden sensorineural hearing loss and Meniere's disease. Dexamethasone inserted IT, diffuse across the round window into the inner ear perilymph where it exerts its therapeutic effects. The investigators review of the literature yielded three animal studies which examined the protective effect of IT dexamethasone in the prevention of cisplatin-induced hearing loss. These studies demonstrated promising results pointing to the potential for IT dexamethasone in the prevention of cisplatin ototoxicity in humans. The purpose of this study is to examine possible protective effect of IT dexamethasone on cisplatin-induced hearing loss, in humans. The study hypothesis is that IT dexamethasone treatment would prevent cisplatin-induced hearing loss.
NCT02266433 ↗ Dexamethasone Versus Ketorolac Injection for the Treatment of Local Inflammatory Hand and Upper Extremity Disorders Terminated New York University School of Medicine Phase 3 2012-08-01 The primary objective of this study is to compare local corticosteroid hand and elbow injections to placebo or ketorolac to determine if there is an equal or better reduction of symptoms for common orthopaedic upper extremity disorders including: De Quervain's tenosynovitis, trigger fingers, and tennis elbow (lateral epicondylitis). The investigators will enroll 780 subjects, divided equally into three arms for each disease process, and compare the efficacy of Ketorolac injections to Dexamethasone injections by measuring patient's functional status scores and pain scores at 0 weeks, 4 weeks, 8 weeks, 12 weeks, and 6 month followup periods, prospectively over time.
NCT02266433 ↗ Dexamethasone Versus Ketorolac Injection for the Treatment of Local Inflammatory Hand and Upper Extremity Disorders Terminated NYU Langone Health Phase 3 2012-08-01 The primary objective of this study is to compare local corticosteroid hand and elbow injections to placebo or ketorolac to determine if there is an equal or better reduction of symptoms for common orthopaedic upper extremity disorders including: De Quervain's tenosynovitis, trigger fingers, and tennis elbow (lateral epicondylitis). The investigators will enroll 780 subjects, divided equally into three arms for each disease process, and compare the efficacy of Ketorolac injections to Dexamethasone injections by measuring patient's functional status scores and pain scores at 0 weeks, 4 weeks, 8 weeks, 12 weeks, and 6 month followup periods, prospectively over time.
>Trial ID >Title >Status >Phase >Start Date >Summary

Clinical Trial Conditions for DEXAMETHASONE SODIUM PHOSPHATE; LIDOCAINE HYDROCHLORIDE

Condition Name

Condition Name for DEXAMETHASONE SODIUM PHOSPHATE; LIDOCAINE HYDROCHLORIDE
Intervention Trials
Tenosynovitis 1
Trigger Finger 1
Cisplatin Ototoxicity 1
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Condition MeSH

Condition MeSH for DEXAMETHASONE SODIUM PHOSPHATE; LIDOCAINE HYDROCHLORIDE
Intervention Trials
Tennis Elbow 1
Ototoxicity 1
Hearing Loss 1
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Clinical Trial Locations for DEXAMETHASONE SODIUM PHOSPHATE; LIDOCAINE HYDROCHLORIDE

Trials by Country

Trials by Country for DEXAMETHASONE SODIUM PHOSPHATE; LIDOCAINE HYDROCHLORIDE
Location Trials
United States 1
Israel 1
China 1
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Trials by US State

Trials by US State for DEXAMETHASONE SODIUM PHOSPHATE; LIDOCAINE HYDROCHLORIDE
Location Trials
New York 1
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Clinical Trial Progress for DEXAMETHASONE SODIUM PHOSPHATE; LIDOCAINE HYDROCHLORIDE

Clinical Trial Phase

Clinical Trial Phase for DEXAMETHASONE SODIUM PHOSPHATE; LIDOCAINE HYDROCHLORIDE
Clinical Trial Phase Trials
Phase 4 1
Phase 3 1
Phase 2 1
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Clinical Trial Status

Clinical Trial Status for DEXAMETHASONE SODIUM PHOSPHATE; LIDOCAINE HYDROCHLORIDE
Clinical Trial Phase Trials
Terminated 1
Unknown status 1
Completed 1
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Clinical Trial Sponsors for DEXAMETHASONE SODIUM PHOSPHATE; LIDOCAINE HYDROCHLORIDE

Sponsor Name

Sponsor Name for DEXAMETHASONE SODIUM PHOSPHATE; LIDOCAINE HYDROCHLORIDE
Sponsor Trials
Meir Medical Center 1
New York University School of Medicine 1
NYU Langone Health 1
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Sponsor Type

Sponsor Type for DEXAMETHASONE SODIUM PHOSPHATE; LIDOCAINE HYDROCHLORIDE
Sponsor Trials
Other 5
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