Intravenous Phenoxybenzamine Use in Pediatric Patients Undergoing Open-Heart Surgery
Completed
Arkansas Children's Hospital Research Institute
Phase 2
2001-02-01
Cardiopulmonary bypass is done with a machine that does the work of the heart and lungs
during open-heart surgery. This study is to determine if intravenous (i.v.) phenoxybenzamine
is safe. This drug lowers the blood pressure, making it easier for the cardiopulmonary bypass
machine to deliver blood and oxygen to all of the organs and tissues.
Intravenous Phenoxybenzamine Use in Pediatric Patients Undergoing Open-Heart Surgery
Completed
University of Arkansas
Phase 2
2001-02-01
Cardiopulmonary bypass is done with a machine that does the work of the heart and lungs
during open-heart surgery. This study is to determine if intravenous (i.v.) phenoxybenzamine
is safe. This drug lowers the blood pressure, making it easier for the cardiopulmonary bypass
machine to deliver blood and oxygen to all of the organs and tissues.
Use of Phenoxybenzamine [PBZ] IV to Assist High Flow Low Pressure Perfusion [HFLPP] on Cardio-pulmonary Bypass
Terminated
The Cleveland Clinic
N/A
2006-06-01
Cardiopulmonary bypass [CPB] in small size bodies can result in decreased peripheral
perfusion. This results in anaerobic metabolism as evidenced by lactic acidosis. High flow
perfusion results in systemic hypertension which is accentuated by moderate hypothermia
commonly used during cardiopulmonary bypass. Phenoxybenzamine [PBZ] is an arteriolar
vasodilator that acts by irreversibly blocking the alpha adrenergic receptors. It causes
vasodilatation allowing high flow, low pressure CPB. It has been used extensively outside US
in Canada, Europe and Australia. In the US oral PBZ is FDA approved, whereas intravenous PBZ
is only available as an investigational drug
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