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Last Updated: November 22, 2024

CLINICAL TRIALS PROFILE FOR DORAVIRINE; LAMIVUDINE; TENOFOVIR DISOPROXIL FUMARATE


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All Clinical Trials for DORAVIRINE; LAMIVUDINE; TENOFOVIR DISOPROXIL FUMARATE

Trial ID Title Status Sponsor Phase Start Date Summary
NCT02397096 ↗ Safety and Efficacy of a Switch to Doravirine, Tenofovir, Lamivudine (MK-1439A) in Human Immunodeficiency Virus (HIV-1)-Infected Participants Virologically Suppressed on an Anti-retroviral Regimen in Combination With Two Nucleoside Reverse Transcrip Active, not recruiting Merck Sharp & Dohme Corp. Phase 3 2015-06-09 The multicenter, open label, randomized study will evaluate the safety and efficacy of a switch to MK-1439A (MK-1439 [doravirine] plus lamivudine and tenofovir disoproxil fumarate) in HIV-1-infected participants virologically suppressed on a protocol-specified antiretroviral regimen. The primary hypothesis is that a switch to doravirine, tenofovir, lamivudine will be non-inferior to continuation of the regimen at Screening for 24 weeks, as assessed by the proportion of participants maintaining HIV-1 ribonucleic acid (RNA) <50 copies/mL. The Base Study results will be based on the first 48 weeks of this ongoing study.
NCT02403674 ↗ Comparison of Doravirine, Tenofovir, Lamivudine (MK-1439A) and ATRIPLA™ in Treatment-Naive Human Immunodeficiency Virus Type 1 (HIV-1)-Infected Participants (MK-1439A-021) Active, not recruiting Merck Sharp & Dohme Corp. Phase 3 2015-06-05 The purpose of this study is to compare the antiretroviral activity of doravirine, tenofovir, lamivudine (MK-1439A), a single-tablet, once-daily (q.d.) fixed-dose combination (FDC) containing doravirine (MK-1439) 100 mg + lamivudine 300 mg + tenofovir disoproxil fumarate 300 mg, with ATRIPLA™, a single-tablet FDC containing efavirenz 600 mg + emtricitabine 200 mg + tenofovir disoproxil fumarate 300 mg, in treatment-naive participants infected with human immunodeficiency virus (HIV). The primary hypothesis is that doravirine, tenofovir, lamivudine q.d. is non-inferior to ATRIPLA™ q.d. as assessed by the proportion of participants with HIV-1 ribonucleic acid (RNA) <50 copies/mL (by the Abbott RealTime HIV-1 Assay) at Week 48. This study has a total duration of 192 weeks, including a 96-week double-blind period and a 96-week open-label period. The present results are based on the first 48 weeks of this ongoing study.
NCT02629822 ↗ Safety and Efficacy of Doravirine, Tenofovir, Lamivudine (MK-1439A) in Participants Infected With Treatment-Naïve Human Immunodeficiency Virus (HIV) -1 With Transmitted Resistance (MK-1439A-030) Completed Merck Sharp & Dohme Corp. Phase 2 2016-01-14 The primary objectives of this study are to evaluate the antiretroviral activity and the safety/tolerability of open-label doravirine/lamivudine/tenofovir disoproxil fumarate (DOR/3TC/TDF; MK-1439A; DELSTRIGO™) consisting of a single fixed-dose combination (FDC) tablet of DOR/3TC/TDF 100 mg/300 mg/300 mg in treatment-naïve HIV-1 infected participants with select non-nucleoside reverse transcriptase inhibitor (NNRTI) transmitted resistance-associated mutations.
NCT03332095 ↗ Evaluating the Pharmacokinetics, Safety, and Tolerability of Doravirine (MK-1439) and Doravirine/Lamivudine/Tenofovir Disoproxil Fumarate (MK-1439A) in HIV-1-Infected Children and Adolescents Active, not recruiting National Institute of Allergy and Infectious Diseases (NIAID) Phase 1/Phase 2 2018-03-21 The purpose of this study is to evaluate the pharmacokinetics, safety, and tolerability of doravirine (also called MK-1439 or DOR) and doravirine/lamivudine/tenofovir disoproxil fumarate (also called MK-1439A or DOR/3TC/TDF) in HIV-1-infected children and adolescents.
>Trial ID >Title >Status >Phase >Start Date >Summary

Clinical Trial Conditions for DORAVIRINE; LAMIVUDINE; TENOFOVIR DISOPROXIL FUMARATE

Condition Name

Condition Name for DORAVIRINE; LAMIVUDINE; TENOFOVIR DISOPROXIL FUMARATE
Intervention Trials
HIV-1-infection 3
Hiv 3
HIV Infections 2
HIV-1 Infection 2
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Condition MeSH

Condition MeSH for DORAVIRINE; LAMIVUDINE; TENOFOVIR DISOPROXIL FUMARATE
Intervention Trials
HIV Infections 6
Acquired Immunodeficiency Syndrome 4
Body Weight 2
Immunologic Deficiency Syndromes 2
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Clinical Trial Locations for DORAVIRINE; LAMIVUDINE; TENOFOVIR DISOPROXIL FUMARATE

Trials by Country

Trials by Country for DORAVIRINE; LAMIVUDINE; TENOFOVIR DISOPROXIL FUMARATE
Location Trials
United States 29
South Africa 7
Russian Federation 5
Spain 5
France 4
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Trials by US State

Trials by US State for DORAVIRINE; LAMIVUDINE; TENOFOVIR DISOPROXIL FUMARATE
Location Trials
Colorado 3
Texas 2
New Jersey 2
Maryland 2
Illinois 2
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Clinical Trial Progress for DORAVIRINE; LAMIVUDINE; TENOFOVIR DISOPROXIL FUMARATE

Clinical Trial Phase

Clinical Trial Phase for DORAVIRINE; LAMIVUDINE; TENOFOVIR DISOPROXIL FUMARATE
Clinical Trial Phase Trials
Phase 4 3
Phase 3 5
Phase 2 3
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Clinical Trial Status

Clinical Trial Status for DORAVIRINE; LAMIVUDINE; TENOFOVIR DISOPROXIL FUMARATE
Clinical Trial Phase Trials
Recruiting 5
Not yet recruiting 3
Active, not recruiting 3
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Clinical Trial Sponsors for DORAVIRINE; LAMIVUDINE; TENOFOVIR DISOPROXIL FUMARATE

Sponsor Name

Sponsor Name for DORAVIRINE; LAMIVUDINE; TENOFOVIR DISOPROXIL FUMARATE
Sponsor Trials
Merck Sharp & Dohme Corp. 5
Professor Francois Venter 2
Willem Daniel Francois Venter 2
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Sponsor Type

Sponsor Type for DORAVIRINE; LAMIVUDINE; TENOFOVIR DISOPROXIL FUMARATE
Sponsor Trials
Other 14
Industry 7
NIH 1
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