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Last Updated: November 22, 2024

CLINICAL TRIALS PROFILE FOR DOXORUBICIN HYDROCHLORIDE (LIPOSOMAL)


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All Clinical Trials for DOXORUBICIN HYDROCHLORIDE (LIPOSOMAL)

Trial ID Title Status Sponsor Phase Start Date Summary
NCT00001059 ↗ Comparison of Liposomal Doxorubicin Used Alone or in Combination With Bleomycin Plus Vincristine in the Treatment of Kaposi's Sarcoma in Patients With AIDS Completed Amgen Phase 2 1969-12-31 To evaluate the safety and efficacy of liposomal doxorubicin hydrochloride ( DOX-SL ) alone or in combination with bleomycin and vincristine in the long-term treatment of AIDS-related Kaposi's sarcoma. To determine whether the 3-drug combination enhances progression-free survival and quality of life. Liposomal formulations of chemotherapeutic agents increase drug accumulation in tumors, which permits disease palliation at relatively low doses and thus decreases some of the dose-limiting toxicity. Multi-agent therapy is considered to be more effective than single-agent therapy; therefore, DOX-SL will be combined with bleomycin and vincristine.
NCT00001059 ↗ Comparison of Liposomal Doxorubicin Used Alone or in Combination With Bleomycin Plus Vincristine in the Treatment of Kaposi's Sarcoma in Patients With AIDS Completed Sequus Pharmaceuticals Phase 2 1969-12-31 To evaluate the safety and efficacy of liposomal doxorubicin hydrochloride ( DOX-SL ) alone or in combination with bleomycin and vincristine in the long-term treatment of AIDS-related Kaposi's sarcoma. To determine whether the 3-drug combination enhances progression-free survival and quality of life. Liposomal formulations of chemotherapeutic agents increase drug accumulation in tumors, which permits disease palliation at relatively low doses and thus decreases some of the dose-limiting toxicity. Multi-agent therapy is considered to be more effective than single-agent therapy; therefore, DOX-SL will be combined with bleomycin and vincristine.
NCT00001059 ↗ Comparison of Liposomal Doxorubicin Used Alone or in Combination With Bleomycin Plus Vincristine in the Treatment of Kaposi's Sarcoma in Patients With AIDS Completed National Institute of Allergy and Infectious Diseases (NIAID) Phase 2 1969-12-31 To evaluate the safety and efficacy of liposomal doxorubicin hydrochloride ( DOX-SL ) alone or in combination with bleomycin and vincristine in the long-term treatment of AIDS-related Kaposi's sarcoma. To determine whether the 3-drug combination enhances progression-free survival and quality of life. Liposomal formulations of chemotherapeutic agents increase drug accumulation in tumors, which permits disease palliation at relatively low doses and thus decreases some of the dose-limiting toxicity. Multi-agent therapy is considered to be more effective than single-agent therapy; therefore, DOX-SL will be combined with bleomycin and vincristine.
NCT00002093 ↗ A Randomized Phase III Clinical Trial of Daunoxome Versus Combination Chemotherapy With Adriamycin/Bleomycin/Vincristine (ABV) in the Treatment of HIV-Associated Kaposi's Sarcoma. Completed Nexstar Pharmaceuticals Phase 3 1969-12-31 To compare the toxicity profiles (severity and time to onset from initiation of therapy) between daunorubicin (liposomal) and combination chemotherapy with doxorubicin/bleomycin/vincristine (ABV), with both regimens administered in combination with antiretroviral therapy. To compare the duration of responses, response rates, and times to response.
>Trial ID >Title >Status >Phase >Start Date >Summary

Clinical Trial Conditions for DOXORUBICIN HYDROCHLORIDE (LIPOSOMAL)

Condition Name

Condition Name for DOXORUBICIN HYDROCHLORIDE (LIPOSOMAL)
Intervention Trials
Ovarian Cancer 67
Breast Cancer 56
Fallopian Tube Cancer 29
Multiple Myeloma 24
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Condition MeSH

Condition MeSH for DOXORUBICIN HYDROCHLORIDE (LIPOSOMAL)
Intervention Trials
Ovarian Neoplasms 126
Carcinoma, Ovarian Epithelial 100
Breast Neoplasms 81
Fallopian Tube Neoplasms 56
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Clinical Trial Locations for DOXORUBICIN HYDROCHLORIDE (LIPOSOMAL)

Trials by Country

Trials by Country for DOXORUBICIN HYDROCHLORIDE (LIPOSOMAL)
Location Trials
Italy 135
China 77
Spain 63
Germany 57
Canada 52
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Trials by US State

Trials by US State for DOXORUBICIN HYDROCHLORIDE (LIPOSOMAL)
Location Trials
California 78
New York 67
Texas 58
Florida 50
Ohio 49
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Clinical Trial Progress for DOXORUBICIN HYDROCHLORIDE (LIPOSOMAL)

Clinical Trial Phase

Clinical Trial Phase for DOXORUBICIN HYDROCHLORIDE (LIPOSOMAL)
Clinical Trial Phase Trials
Phase 4 10
Phase 3 65
Phase 2/Phase 3 8
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Clinical Trial Status

Clinical Trial Status for DOXORUBICIN HYDROCHLORIDE (LIPOSOMAL)
Clinical Trial Phase Trials
Completed 170
Terminated 52
Recruiting 51
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Clinical Trial Sponsors for DOXORUBICIN HYDROCHLORIDE (LIPOSOMAL)

Sponsor Name

Sponsor Name for DOXORUBICIN HYDROCHLORIDE (LIPOSOMAL)
Sponsor Trials
National Cancer Institute (NCI) 67
Merck Sharp & Dohme Corp. 12
M.D. Anderson Cancer Center 12
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Sponsor Type

Sponsor Type for DOXORUBICIN HYDROCHLORIDE (LIPOSOMAL)
Sponsor Trials
Other 395
Industry 247
NIH 70
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