Vitamin D, Chronic Kidney Disease (CKD) and the Microcirculation
Completed
Barts & The London NHS Trust
Phase 4
2009-04-01
Overall research aims: This study will examine the effect of vitamin D supplementation on the
function of the endothelium and microcirculation of patients with chronic kidney disease and
vitamin D deficiency.
Hypothesis: Vitamin D therapy in patients with CKD and concomitant vitamin D deficiency will
improve endothelial, and therefore microcirculatory function, reduce levels of oxidative
stress and thus reduce the risk of future CVS events in this population.
Vitamin D Supplementation in Psychiatric Illnesses
Completed
University of Massachusetts, Worcester
N/A
2009-06-01
Children and adolescents with psychiatric illnesses who are treated with medications called
second generation antipsychotic agents (SGA) often gain excessive weight during their
treatment with these medications. This weight gain may result in the development of features
of the metabolic syndrome or frank diabetes mellitus. There is no consensus on the best way
to prevent these complications. The investigators' hypothesis is that daily vitamin D
supplementation in these patients will result in decreased levels of the markers of metabolic
syndrome with associated reduction in waist circumference.
Vitamin D and Inflammatory Markers of Cardiovascular Disease in African Americans With Type 2 Diabetes
Unknown status
Rush University
Phase 4
2007-04-01
Recent clinical trials in non diabetics showed that vitamin D supplementation markedly
reduced serum levels of C-reactive protein (CRP), interleukin-6, and tissue matrix
metallo-proteinases. Our study objective is to evaluate if administration of vitamin D in
African Americans with hypovitaminosis D and DM Type 2 decreases serum levels of
inflammatory/thrombotic markers such as CRP: Highly Sensitive C Reactive Protein.
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