Efficacy and Safety Proof of Concept Study in Patients With Parkinson's Disease and End-of-dose Motor Fluctuations
Completed
Orion Corporation, Orion Pharma
Phase 2
2011-05-01
The primary objective of the study is to assess the efficacy, carbidopa dose response and
safety of ODM-101, a new combination of levodopa, carbidopa and entacapone in the treatment
of Parkinson's disease (PD) patients with end-of-dose motor fluctuations.
Clinical Trial of Tolcapone for Cognition in Schizophrenia
Terminated
National Institute of Mental Health (NIMH)
Phase 2
2002-08-01
This study will evaluate whether Tolcapone improves cognition in healthy volunteers as well
as patients with schizophrenia. Talcapone is a drug that has been FDA approved for Attention
Deficit Disorder and allegedly increase the amount of the neurotransmitter dopamine in the
frontal cortex of the brain.
...
Efficacy and Safety of Carbidopa/Levodopa/Entacapone in Patients With Parkinson's Disease Requiring Initiation of Levodopa Therapy
Completed
Orion Corporation, Orion Pharma
Phase 3
2004-09-01
The CELC200A2401 study has been designed in order to evaluate the hypothesis that
administering the combination carbidopa/levodopa/entacapone at the time that levodopa therapy
is initiated results in a decrease in the risk of the development of motor complications for
patients with Parkinson's disease.
Efficacy and Safety of Carbidopa/Levodopa/Entacapone in Patients With Parkinson's Disease Requiring Initiation of Levodopa Therapy
Completed
Novartis Pharmaceuticals
Phase 3
2004-09-01
The CELC200A2401 study has been designed in order to evaluate the hypothesis that
administering the combination carbidopa/levodopa/entacapone at the time that levodopa therapy
is initiated results in a decrease in the risk of the development of motor complications for
patients with Parkinson's disease.
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