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Last Updated: November 22, 2024

CLINICAL TRIALS PROFILE FOR EPINEPHRINE (AUTOINJECTOR)


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All Clinical Trials for EPINEPHRINE (AUTOINJECTOR)

Trial ID Title Status Sponsor Phase Start Date Summary
NCT03964051 ↗ Protection From Food Induced Anaphylaxis by Reducing the Serum Level of Specific IgE (Protana). Active, not recruiting Miltenyi Biomedicine GmbH Phase 4 2019-07-01 Anaphylaxis elicited by accidental intake of the offending food constitutes a major health risk to the food allergic patient. Current advice for the food allergic patient is to avoid the offending food allergen and to carry an epinephrine autoinjector. However, novel treatments altering the clinical reactivity to the offending food thereby diminishing the risk of anaphylaxis are much needed. A correlation between the level of specific IgE in serum towards the offending food and the clinical sensitivity of the patient has been suggested. The clinical threshold for a food allergic reaction to occur is therefore hypothesized to increase by reducing the level of specific IgE to the relevant food allergen. Therapy with Omalizumab has proven efficacious in lowering the level of IgE in serum but a high pre-treatment level of total IgE in serum potentially hampers the efficacy in a number of patients, as seen especially in patients with concomitant atopic dermatitis. The aim of this study is to investigate if the combination of initial IgE specific immunoadsorption combined with subsequent treatment with Omalizumab will increase the clinical threshold to the culprit food and thus prevent medical emergencies (anaphylaxis) in patients with severe food allergy.
NCT03964051 ↗ Protection From Food Induced Anaphylaxis by Reducing the Serum Level of Specific IgE (Protana). Active, not recruiting Miltenyi Biotec GmbH Phase 4 2019-07-01 Anaphylaxis elicited by accidental intake of the offending food constitutes a major health risk to the food allergic patient. Current advice for the food allergic patient is to avoid the offending food allergen and to carry an epinephrine autoinjector. However, novel treatments altering the clinical reactivity to the offending food thereby diminishing the risk of anaphylaxis are much needed. A correlation between the level of specific IgE in serum towards the offending food and the clinical sensitivity of the patient has been suggested. The clinical threshold for a food allergic reaction to occur is therefore hypothesized to increase by reducing the level of specific IgE to the relevant food allergen. Therapy with Omalizumab has proven efficacious in lowering the level of IgE in serum but a high pre-treatment level of total IgE in serum potentially hampers the efficacy in a number of patients, as seen especially in patients with concomitant atopic dermatitis. The aim of this study is to investigate if the combination of initial IgE specific immunoadsorption combined with subsequent treatment with Omalizumab will increase the clinical threshold to the culprit food and thus prevent medical emergencies (anaphylaxis) in patients with severe food allergy.
NCT03964051 ↗ Protection From Food Induced Anaphylaxis by Reducing the Serum Level of Specific IgE (Protana). Active, not recruiting Carsten Bindslev-Jensen Phase 4 2019-07-01 Anaphylaxis elicited by accidental intake of the offending food constitutes a major health risk to the food allergic patient. Current advice for the food allergic patient is to avoid the offending food allergen and to carry an epinephrine autoinjector. However, novel treatments altering the clinical reactivity to the offending food thereby diminishing the risk of anaphylaxis are much needed. A correlation between the level of specific IgE in serum towards the offending food and the clinical sensitivity of the patient has been suggested. The clinical threshold for a food allergic reaction to occur is therefore hypothesized to increase by reducing the level of specific IgE to the relevant food allergen. Therapy with Omalizumab has proven efficacious in lowering the level of IgE in serum but a high pre-treatment level of total IgE in serum potentially hampers the efficacy in a number of patients, as seen especially in patients with concomitant atopic dermatitis. The aim of this study is to investigate if the combination of initial IgE specific immunoadsorption combined with subsequent treatment with Omalizumab will increase the clinical threshold to the culprit food and thus prevent medical emergencies (anaphylaxis) in patients with severe food allergy.
NCT05166343 ↗ POHCA Resuscitation: Evaluation of IM Epinephrine Not yet recruiting Lawson Health Research Institute Phase 2/Phase 3 2022-01-01 This is a pragmatic, two-arm, open-label, prospective stepped-wedge cluster randomized control trial (SW-CRCT) looking to evaluate early intramuscular (IM) epinephrine in the management of pediatric out-of-hospital cardiac arrest (POHCA).
>Trial ID >Title >Status >Phase >Start Date >Summary

Clinical Trial Conditions for EPINEPHRINE (AUTOINJECTOR)

Condition Name

Condition Name for EPINEPHRINE (AUTOINJECTOR)
Intervention Trials
Pediatric Out-of-Hospital Cardiac Arrest 1
Food Allergy 1
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Condition MeSH

Condition MeSH for EPINEPHRINE (AUTOINJECTOR)
Intervention Trials
Anaphylaxis 1
Out-of-Hospital Cardiac Arrest 1
Heart Arrest 1
Food Hypersensitivity 1
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Clinical Trial Locations for EPINEPHRINE (AUTOINJECTOR)

Trials by Country

Trials by Country for EPINEPHRINE (AUTOINJECTOR)
Location Trials
Denmark 1
Canada 1
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Clinical Trial Progress for EPINEPHRINE (AUTOINJECTOR)

Clinical Trial Phase

Clinical Trial Phase for EPINEPHRINE (AUTOINJECTOR)
Clinical Trial Phase Trials
Phase 4 1
Phase 2/Phase 3 1
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Clinical Trial Status

Clinical Trial Status for EPINEPHRINE (AUTOINJECTOR)
Clinical Trial Phase Trials
Not yet recruiting 1
Active, not recruiting 1
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Clinical Trial Sponsors for EPINEPHRINE (AUTOINJECTOR)

Sponsor Name

Sponsor Name for EPINEPHRINE (AUTOINJECTOR)
Sponsor Trials
Miltenyi Biomedicine GmbH 1
Miltenyi Biotec GmbH 1
Carsten Bindslev-Jensen 1
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Sponsor Type

Sponsor Type for EPINEPHRINE (AUTOINJECTOR)
Sponsor Trials
Industry 2
Other 2
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