Exenatide Compared With Twice-Daily Biphasic Insulin Aspart in Patients With Type 2 Diabetes Using Sulfonylurea and Metformin
Completed
Eli Lilly and Company
Phase 3
2003-11-01
This is a Phase 3, multicenter, open-label, comparator-controlled trial comparing the effect
of exenatide twice daily to twice daily biphasic insulin aspart on glycemic control, as
measured by hemoglobin A1c (HbA1c).
Exenatide Compared With Twice-Daily Biphasic Insulin Aspart in Patients With Type 2 Diabetes Using Sulfonylurea and Metformin
Completed
AstraZeneca
Phase 3
2003-11-01
This is a Phase 3, multicenter, open-label, comparator-controlled trial comparing the effect
of exenatide twice daily to twice daily biphasic insulin aspart on glycemic control, as
measured by hemoglobin A1c (HbA1c).
Study Looking at Cardiovascular Effects of Exenatide, Its Blood Pressure Lowering Effect and Its Mechanisms
Completed
University of Nottingham
N/A
2009-09-01
Exenatide is a new drug which lowers blood sugar (glucose) levels for people with type 2
diabetes. It has significant advantages over other treatments such as insulin as it causes
weight loss in a group of people that is generally overweight. Data from studies involving
exenatide have shown that it also has an effect on blood pressure. The mechanism for the
blood pressure lowering effect is not known and has not been investigated previously.
Exenatide may have an effect on blood vessels throughout the body and gut to reduce blood
pressure. 12 healthy men (18-45yr) will be studied on 2 occasions. Limb blood flow, skin
blood flow, gut blood flow, blood pressure, and heart rate will be measured half hourly for 4
hours. Blood samples (3ml) for insulin and glucose determination will be taken via a cannula
and 3-way tap at the same time points. A dose of either 5μg exenatide or saline will be
injected under the skin of the abdomen and a breakfast will be provided during the study. A
urine collection will be made over the duration of the study.
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