Extension Study of the Efficacy and Safety of Deferasirox Treatment in Beta-thalassemia Patients With Transfusional Hemosiderosis (Study Amended to 2-year Duration)
Completed
Novartis Pharmaceuticals
Phase 4
2005-06-01
To allow patients treated with deferasirox in the core study to continue iron chelation
therapy for 2 years or until the drug became locally commercially available. To evaluate the
long-term safety and efficacy of deferasirox by measuring treatment success, change in liver
iron content (LIC) and change in serum ferritin levels. Safety was mainly assessed by
incidence of adverse events (AEs)and clinically significant lab parameters.
Expanded Access of Deferasirox to Patients With Congenital Disorders of Red Blood Cells and Chronic Iron Overload
Completed
Novartis Pharmaceuticals
Phase 3
2005-10-01
This is an open-label, non-randomized, multi-center trial designed to provide expanded access
of deferasirox to patients with congenital disorders of red blood cells and chronic iron
overload from blood transfusions who cannot adequately be treated with locally approved iron
chelators.
The Deferasirox-AmBisome Therapy for Mucormycosis (DEFEAT Mucor) Study
Completed
Astellas Pharma Inc
Phase 2
2007-10-01
The purpose of this study is to determine if the addition of the medication, deferasirox, to
standard antifungal therapy for the infection, mucormycosis, is safe and effective
The Deferasirox-AmBisome Therapy for Mucormycosis (DEFEAT Mucor) Study
Completed
Gilead Sciences
Phase 2
2007-10-01
The purpose of this study is to determine if the addition of the medication, deferasirox, to
standard antifungal therapy for the infection, mucormycosis, is safe and effective
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