Medication Development in Alcoholism: Investigating PPAR Agonists
Completed
National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Phase 2
2014-05-01
The primary hypotheses under test are that alcohol dependent subjects treated with
fenofibrate will report decreased craving for alcohol following cue-exposure in the
laboratory and report less drinking post treatment relative to placebo.
Medication Development in Alcoholism: Investigating PPAR Agonists
Completed
The Scripps Research Institute
Phase 2
2014-05-01
The primary hypotheses under test are that alcohol dependent subjects treated with
fenofibrate will report decreased craving for alcohol following cue-exposure in the
laboratory and report less drinking post treatment relative to placebo.
Fenofibrate in Patients With Cervical Intraepithelial Neoplasia and Invasive Cervical Carcinoma
Not yet recruiting
Lindsay Ferguson, MD
Phase 1
2024-08-01
Normally, p53 helps prevent tumors from forming in the body. Early studies have shown that
Fenofibrate, a cholesterol-lowering drug, can restore normal function to p53 and can change
the metabolism of HPV-positive tumors in a way that stops the growth of tumors. The purpose
of this study is to understand how Fenofibrate can be used to treat HPV-positive cervical
cancers and cervical dysplasia. Researchers will examine collected tissue samples and
investigate various genes and proteins to see whether Fenofibrate has an effect on
HPV-positive cervical cancers and cervical dysplasia.
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