The Addition of Montelukast to Fluticasone in the Treatment of Perennial Allergic Rhinitis
Terminated
Merck Sharp & Dohme Corp.
Phase 4
2005-07-01
Some people with nasal allergy symptoms continue to have symptoms even after treatment with a
nasal steroid spray. The purpose of this study is to see if these patients are helped by
adding another medication (montelukast) to their treatment compared to placebo (a substance
that looks like the active medication but does not contain the drug).
The Addition of Montelukast to Fluticasone in the Treatment of Perennial Allergic Rhinitis
Terminated
University of Chicago
Phase 4
2005-07-01
Some people with nasal allergy symptoms continue to have symptoms even after treatment with a
nasal steroid spray. The purpose of this study is to see if these patients are helped by
adding another medication (montelukast) to their treatment compared to placebo (a substance
that looks like the active medication but does not contain the drug).
Topical Steroid Treatment for Eosinophilic Esophagitis
Completed
Mayo Clinic
Phase 2
2005-11-01
This was a randomized controlled trial of swallowed fluticasone vs. placebo for eosinophilic
esophagitis. Eosinophilic esophagitis is an inflammatory condition in which the wall of the
esophagus becomes filled with large numbers of eosinophils, a type of white blood cell.
Patients who have this condition have difficulty in swallowing (dysphagia) solid food.
Prior to treatment the patients had biopsies of their esophagus and took questionnaires
regarding their symptoms. Treatment was given for 6 weeks, after which biopsies were taken
from the esophagus to measure any changes in the tissue from before treatment. The primary
endpoint was improvement in dysphagia as measured by the validated Mayo Dysphagia
Questionaire. Secondary outcomes included partial symptom response, and histologic (tissue)
response to treatment.
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