Short-course Methenamine Hippurate for Prevention of Post-operative UTI
Completed
University of Pennsylvania
N/A
2014-12-01
The investigators will determine the efficacy of an innovative short regimen of methenamine
hippurate on prevention of post-operative UTI in patients requiring short-term
catheterization after pelvic reconstructive surgery through a single-blind, randomized
controlled trial. Primary outcome will be the rate of symptomatic UTI within 3 weeks of
catheter removal. The investigators will study cost-effectiveness, antibiotic resistance
profiles, and adverse drug effects. Findings may reduce antibiotic use and nosocomial UTIs.
Efficacy and Mechanism of Action of Methenamine Hippurate (Hiprex™) in Women With Recurring Urinary Tract Infections.
Recruiting
University of Texas Southwestern Medical Center
Phase 4
2021-01-04
The purpose of this study is to measure the concentration of formaldehyde in the urine of
women with recurrent urinary tract infections on Hiprex; and then, assuming its urinary
presence is confirmed at the proper acid urinary pH, evaluate if such a therapy has favorable
effects in decreasing the rate of recurrent urinary tract infections over time.
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