Phase II Study of Amithiozone (Thiacetazone) for Patients With Mycobacterium Avium Complex Pulmonary Disease
Completed
National Jewish Health
Phase 2
1991-01-01
OBJECTIVES: I. Determine the bacteriological activity of amithiozone against Mycobacterium
avium complex (MAC) pulmonary disease.
II. Define the ability of amithiozone to improve clinical outcomes in patients with MAC
infection.
III. Determine the safety and tolerance of amithiozone with chronic dosing in these patients.
IV. Assess the contribution of clarithromycin, streptomycin, rifampin, ethambutol, kanamycin,
and amithiozone in the treatment of pulmonary MAC infection.
Pharmacokinetic Study of Antiretroviral Drugs and Related Drugs During and After Pregnancy
Completed
Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
2003-03-01
The purpose of this study is to evaluate the pharmacokinetics (PKs) of antiretroviral (ARV)
and tuberculosis (TB) medications in pregnant women and their infants. (Pharmacokinetics are
the various interactions between a drug and the body.) This study will also evaluate the PKs
of certain ARVs in postpartum women before and after starting hormonal contraceptives. The
PKs of these drugs will be evaluated by measuring the amount of medicine present in blood
and/or vaginal secretions.
Pharmacokinetic Study of Antiretroviral Drugs and Related Drugs During and After Pregnancy
Completed
National Institute of Allergy and Infectious Diseases (NIAID)
2003-03-01
The purpose of this study is to evaluate the pharmacokinetics (PKs) of antiretroviral (ARV)
and tuberculosis (TB) medications in pregnant women and their infants. (Pharmacokinetics are
the various interactions between a drug and the body.) This study will also evaluate the PKs
of certain ARVs in postpartum women before and after starting hormonal contraceptives. The
PKs of these drugs will be evaluated by measuring the amount of medicine present in blood
and/or vaginal secretions.
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