Alcohol Detoxification in Primary Care Treatment (ADEPT)
Completed
University of Bristol
Phase 4
2009-11-01
Once someone becomes dependent on alcohol (alcoholic), the risks of complications from
alcohol withdrawal when they stop drinking grow. These can include a life-threatening fit or
delirium tremens (see things, become frightened). To prevent such complications, people take
medication such as benzodiazepines (e.g., valium or librium) in reducing doses for about a
week; this is called detoxification or 'detox.' In the UK effective alcohol treatment exists
but little is known about what is the best detox medication. Alternative drugs to
benzodiazepines appear to protect the brain from the toxicity of alcohol withdrawal and to
reduce the likelihood of drinking again. This study will examine the feasibility of comparing
medication regimens for alcohol detox for the first time in primary care. It will include a
standard detox regimen (librium over 8 days) alone and together with a drug, acamprosate,
that has been shown to reduce toxicity of alcohol withdrawal in preclinical models and is
used after detox to help people remain sober. It will focus on the practicalities of doing
such a study as well as assessing how people feel (withdrawal symptoms) and do (drinking
during first month).
Gabapentin vs Chlordiazepoxide for Ambulatory Alcohol Withdrawal
Completed
VA Salt Lake City Health Care System
Phase 4
2004-03-01
A randomized, double-blind controlled trial comparing treatment outcomes between
chlordiazepoxide, or gabapentin to treat alcohol withdrawal syndrome in alcohol dependent
veteran subjects. The objective of this trial is to compare the safety and effectiveness of
these two medications. Intervention is a fixed dose taper of chlordiazepoxide, or gabapentin
over 6 days. Subjects will be evaluated for 7-10 days to monitor alcohol abstinence,
withdrawal severity scores, adverse events including ataxia, sedation, cognitive function and
alcohol craving.
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