Local Anaesthetic Effects of Transcutaneous Amitriptyline
Completed
University Hospital, Clermont-Ferrand
Phase 1
2005-11-01
The aim of this study is to assess the local anaesthetic effects of amitriptyline applied on
the skin of human volunteers, considering the differential effects on mechanic and thermic
sensitivity, the local and general tolerance, and the systemic absorption of the drug. The
solution used for dilution of amitriptyline is the only one known to allow transcutaneous
absorption of the drug [1]. Considering that the peripheral sensitive fibre is a possible
site of action of tricyclic antidepressants for relieving neuropathic pain [2,3], this is a
first step study before further assessment of the therapeutic effects of transcutaneous
amitriptyline.
Phase I Study of PSD502 (Lidocaine Prilocaine Spray) Applied to the Glans Penis up to Three Times a Day for 21 Days in Healthy Male Volunteers
Completed
Plethora Solutions Ltd
Phase 1
2007-03-01
The main objective of the study is to determine the safety and tolerability of repeated
application of PSD502 to the glans penis in healthy male volunteers
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