Diphenoxylate / Atropine to Decrease FDG Activity During F-18 FDG PET
Completed
Mayo Clinic
Phase 3
2003-02-01
2-[18F]-fluoro-2-deoxyD-glucose positron emission tomography (FDG PET) has proven to be a
valuable clinical tool for the staging and surveillance of lymphoma.1-6 Occasionally, lymph
nodes in the mesentery and retroperitoneum can be difficult to distinguish from normal bowel
activity on PET scans despite three-plane and cine maximal image projection (MIP) imaging.
This uncertainty limits the clinical usefulness of PET in some cases of lymphoma.7-8 In
addition, bowel activity can also hinder interpretation of PET scans in other types of solid
tumors including melanoma and colorectal cancer.6,9,10 Our goal is to determine how well
diphenoxylate/atropine 5mg/0.05mg (Lomotil) decreases bowel activity and how this decrease
impacts clinical decision-making, specifically for lymphoma staging and surveillance. This is
a prospective, randomized, double-blinded study involving 60 patients undergoing PET scans
for newly diagnosed or recurrent, untreated lymphoma.
Efficacy of Loperamide for C. Difficile Colitis and Other Diarrheal Diseases Associated With Antibiotic Therapy
Suspended
Michael E. DeBakey VA Medical Center
Phase 4
2007-10-01
To determine whether symptomatic treatment of the diarrhea in CDAD reduces morbidity and
mortality of this serious nosocomial infection in patients who have antibiotic-associated
diarrhea. Both C. diff positive and negative patients will be included.
Efficacy of Loperamide for C. Difficile Colitis and Other Diarrheal Diseases Associated With Antibiotic Therapy
Suspended
VA Medical Center, Houston
Phase 4
2007-10-01
To determine whether symptomatic treatment of the diarrhea in CDAD reduces morbidity and
mortality of this serious nosocomial infection in patients who have antibiotic-associated
diarrhea. Both C. diff positive and negative patients will be included.
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