CLINICAL TRIALS PROFILE FOR MEPIVACAINE HYDROCHLORIDE

All Clinical Trials for MEPIVACAINE HYDROCHLORIDE

Trial ID	Title	Status	Sponsor	Phase	Start Date	Summary
NCT00121329 ↗	4% Intrauterine Lidocaine Infusion for Pain Management in First Trimester Abortions	Completed	Oregon Health and Science University	N/A	1969-12-31	Recent studies have investigated the use of local anesthetics (i.e. lidocaine, mepivacaine) to lessen the pain experienced with minor gynecologic procedures such as endometrial biopsy and office hysteroscopy. Local anesthetic injected into the uterine cavity has been demonstrated effective in some studies at decreasing patient pain associated with these intrauterine procedures at an anesthetic concentration of at least 2%. Based on this evidence, we hypothesized that an intrauterine lidocaine infusion may reduce patient pain during first trimester abortions.
NCT00154167 ↗	Safety and Efficacy Study of NV-101 in Dental Patients	Completed	Novalar Pharmaceuticals, Inc.	Phase 2	2003-02-01	The purpose of this study was: - to determine if NV-101 accelerates recovery from numbness compared to placebo - to evaluate safety of NV-101
NCT00567450 ↗	Ropivacaine Versus Ropivacaine Plus Mepivacaine for Sciatic Block	Completed	Centre Hospitalier Universitaire, Amiens	Phase 4	2007-09-01	In loco regional anesthesia, much more than for general anesthesia, the choice of the product is largely left at the discretion of the practitioner. Two categories of local anesthetics are distinguished according to their pharmacodynamic characteristics: products with a short time of installation and a short duration period, and products with a longer delay of installation of the sensitive and motor block, but with a long-term duration. Indeed, the combined use of two products pharmacodynamically different seems to be of a practical interest. This study provides a comparison of the onset of action of 30 ml of ropivacaine 0.75% and 30ml of a mixture of ropivacaïne 0.75% associated with mepivacaïne 1.5% for the subgluteal sciatic nerve block. This is a prospective randomized double-blind study where the main criterion of judgment is the time of installation of a sensitive block compatible with surgery in the sciatic territory nerve. Fifteen patients per group were calculated to detect a 50% decrease of the onset of action in the combination group with a power of 90% and alpha to 5%, according to a previous pilot study. The secondary endpoints are the intensity and time of installation of the motor block, the duration of sensitive and motor block, the total dose of morphine administered within 48 hours, as well as its possible side effects.
NCT00803725 ↗	Spinal Mepivicaine With Fentanyl for Outpatient Knee Arthroscopy	Completed	University Health Network, Toronto	N/A	2008-08-01	The purpose of this study is to determine if the addition of intrathecal fentanyl to low dose mepivacaine spinal anesthesia provides adequate surgical anesthesia with shorter duration of motor blockade. It is hypothesized that lower doses of spinal mepivacaine when combined with fentanyl will result in adequate surgical block for knee arthroscopy surgery with faster recovery and discharge compared to mepivacaine alone.
NCT00825786 ↗	Ultrasound Guided Supraclavicular Nerve Block	Completed	The Cleveland Clinic	Phase 3	2008-09-01	This study will test the hypothesis that sequential injection of 1.5% mepivacaine followed 90 seconds later by 0.5% ropivacaine in ultrasound guided supraclavicular block provides a quicker onset and a longer duration of analgesia than an equi-dose mixture of the two local anesthetics.
NCT00841841 ↗	Dipyrone Versus Acetaminophen in the Control of Postoperative Pain	Completed	University of Sao Paulo	Phase 2	2006-03-01	Adequate postoperative pain management is challenging for practitioners despite recent advances in pain control techniques and analgesic agents. The purpose of this study is to compare the efficacy of Dipyrone and acetaminophen in postoperative pain after third molar surgery.
NCT00841841 ↗	Dipyrone Versus Acetaminophen in the Control of Postoperative Pain	Completed	University Center of Araraquara	Phase 2	2006-03-01	Adequate postoperative pain management is challenging for practitioners despite recent advances in pain control techniques and analgesic agents. The purpose of this study is to compare the efficacy of Dipyrone and acetaminophen in postoperative pain after third molar surgery.

Clinical Trial Conditions for MEPIVACAINE HYDROCHLORIDE

Condition Name

Condition Name for MEPIVACAINE HYDROCHLORIDE
Intervention	Trials
Symptomatic Irreversible Pulpitis	8
Pain	7
Postoperative Pain	4
Anesthesia	4

Condition MeSH

Condition MeSH for MEPIVACAINE HYDROCHLORIDE
Intervention	Trials
Pulpitis	14
Pain, Postoperative	9
Osteoarthritis, Hip	3
Osteoarthritis	3

Clinical Trial Locations for MEPIVACAINE HYDROCHLORIDE

Trials by Country

Trials by Country for MEPIVACAINE HYDROCHLORIDE
Location	Trials
United States	23
Egypt	8
Brazil	7
Italy	4
Spain	4

Trials by US State

Trials by US State for MEPIVACAINE HYDROCHLORIDE
Location	Trials
Tennessee	2
Pennsylvania	2
New York	2
California	2
Ohio	2

Clinical Trial Progress for MEPIVACAINE HYDROCHLORIDE

Clinical Trial Phase

Clinical Trial Phase for MEPIVACAINE HYDROCHLORIDE
Clinical Trial Phase	Trials
Phase 4	31
Phase 3	7
Phase 2/Phase 3	5

Clinical Trial Status

Clinical Trial Status for MEPIVACAINE HYDROCHLORIDE
Clinical Trial Phase	Trials
Completed	52
Not yet recruiting	11
Unknown status	8

Clinical Trial Sponsors for MEPIVACAINE HYDROCHLORIDE

Sponsor Name

Sponsor Name for MEPIVACAINE HYDROCHLORIDE
Sponsor	Trials
Cairo University	12
University of Sao Paulo	4
Vanderbilt University	2

Sponsor Type

Sponsor Type for MEPIVACAINE HYDROCHLORIDE
Sponsor	Trials
Other	100
Industry	3
U.S. Fed	1