Cardiac Arrest in Seattle: Conventional Versus Amiodarone Drug Evaluation (CASCADE)
Completed
National Heart, Lung, and Blood Institute (NHLBI)
Phase 3
1987-04-01
To compare the efficacy of amiodarone to conventional anti-arrhythmic therapy in individuals
who had survived one episode of out-of-hospital cardiac arrest.
Cardiac Arrest in Seattle: Conventional Versus Amiodarone Drug Evaluation (CASCADE)
Completed
University of Washington
Phase 3
1987-04-01
To compare the efficacy of amiodarone to conventional anti-arrhythmic therapy in individuals
who had survived one episode of out-of-hospital cardiac arrest.
Electrophysiologic Study Versus Electrocardiographic Monitoring (ESVEM)
Completed
National Heart, Lung, and Blood Institute (NHLBI)
Phase 3
1985-07-01
To determine whether electrophysiologic study (EPS) or Holter monitoring (HM) was the better
method for selecting effective long-term antiarrhythmic drug therapy in patients with
sustained ventricular tachycardia, ventricular fibrillation, or an episode of aborted sudden
death.
Electrophysiologic Study Versus Electrocardiographic Monitoring (ESVEM)
Completed
University of Utah
Phase 3
1985-07-01
To determine whether electrophysiologic study (EPS) or Holter monitoring (HM) was the better
method for selecting effective long-term antiarrhythmic drug therapy in patients with
sustained ventricular tachycardia, ventricular fibrillation, or an episode of aborted sudden
death.
A Phase II/III Double-Blind Study of Amitriptyline and Mexiletine for Painful Neuropathy in HIV Infection
Completed
Boehringer Ingelheim
Phase 2
1969-12-31
To assess the efficacy, safety, and tolerability of amitriptyline hydrochloride versus
mexiletine hydrochloride in reducing pain intensity in patients with HIV-related painful
peripheral neuropathy.
No large-scale controlled clinical trials of symptomatic therapy for painful HIV-related
neuropathy have been attempted. Both amitriptyline and mexiletine have been useful in the
management of painful neuropathies; however, both are associated with certain toxicities. In
this comparative study of amitriptyline and mexiletine, benztropine mesylate also will be
included as an active placebo to mimic the side effects of the study drugs.
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