Efficacy and Safety of Pioglitazone in Treating Subjects With Vascular Complications Associated With Type 2 Diabetes Mellitus.
Completed
Takeda
Phase 4
2009-03-01
The purpose of this study is to determine the efficacy of pioglitazone compared to
glibenclamide, once daily (QD), taken together with metformin and lifestyle modification in
type 2 diabetic subjects with cardiovascular disease.
To Compare the Effect of a Subcutaneous Canakinumab Administration to Placebo in Patients With Impaired Glucose Tolerance or Patients With Type 2 Diabetes With Differing Baseline Diabetes Therapies
Completed
Novartis
Phase 2
2010-02-01
This was a 10-week, placebo-controlled, randomized study to investigate the effect of
injectable IL-1B antagonist, Canakinumab , in participants with impaired glucose tolerance or
Type 2 Diabetes Mellitus (T2DM) already treated on different background diabetes therapies.
Glyburide is a medication that has been safely used for several decades to treat non-insulin
dependent diabetes. This pilot study seeks to evaluate whether glyburide, administered at the
lowest dose (1.5 mg/dL daily) to healthy (non-diabetic) subjects is safe both physically and
cognitively. The investigators are hopeful that the results of this study will provide the
necessary foundation to evaluate this medication's use on a larger scale to determine the
feasibility of using glyburide in soldiers either prophylactically or for the treatment of
brain injury.
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