CLINICAL TRIALS PROFILE FOR MIFEPREX
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All Clinical Trials for MIFEPREX
| Trial ID | Title | Status | Sponsor | Phase | Start Date | Summary |
|---|---|---|---|---|---|---|
| NCT00352911 ↗ | Antiviral Activity and Safety of Mifepristone at 2 Doses in HIV-1 Infected Subjects | Completed | VGX Pharmaceuticals, LLC | Phase 2 | 2006-07-01 | The objective of the study is to determine whether mifepristone (VGX-410) has anti-HIV-1 activity at doses of either 300 mg or 600 mg per day after oral administration for 14 days at each dose level. |
| NCT01224509 ↗ | The Effect of Mifepristone on the Expression of Cervical Prostaglandin EP3 Receptors | Terminated | University of Southern California | N/A | 2004-09-01 | The purpose of this study is to determine the effect of mifepristone on the expression of three cervical EP3 receptor isoforms (EP3-2, EP3-3 and EP3-6) in pregnant women ≤63 days gestational age. |
| NCT01333098 ↗ | Antiglucocorticoid Therapy for Cognitive Impairment in Late-life Anxiety Disorders | Completed | Eric Lenze | Phase 1/Phase 2 | 2012-09-01 | This study seeks to develop and test a novel, mechanistic treatment for mitigating cognitive impairment in older adults with anxiety disorders. Anxiety disorders are common, severe, and disabling in older adults. One particularly impairing aspect of late-life anxiety disorders is cognitive impairment: impairments in memory and executive function cause disability, impede treatment response to psychotherapy, may lead to dementia, and are not corrected by standard anti-anxiety treatments. This pilot study will test the glucocorticoid antagonist, mifepristone, for cognitive impairment in late-life anxiety disorders. Mifepristone blocks the effects of elevated cortisol levels on glucocorticoid receptors in the brain; it has been studied preliminarily in various neuropsychiatric disorders, such as psychotic depression and bipolar disorder, with well-documented safety and tolerability. |
| NCT01333098 ↗ | Antiglucocorticoid Therapy for Cognitive Impairment in Late-life Anxiety Disorders | Completed | Washington University School of Medicine | Phase 1/Phase 2 | 2012-09-01 | This study seeks to develop and test a novel, mechanistic treatment for mitigating cognitive impairment in older adults with anxiety disorders. Anxiety disorders are common, severe, and disabling in older adults. One particularly impairing aspect of late-life anxiety disorders is cognitive impairment: impairments in memory and executive function cause disability, impede treatment response to psychotherapy, may lead to dementia, and are not corrected by standard anti-anxiety treatments. This pilot study will test the glucocorticoid antagonist, mifepristone, for cognitive impairment in late-life anxiety disorders. Mifepristone blocks the effects of elevated cortisol levels on glucocorticoid receptors in the brain; it has been studied preliminarily in various neuropsychiatric disorders, such as psychotic depression and bipolar disorder, with well-documented safety and tolerability. |
| NCT01436279 ↗ | Mifepristone Versus Osmotic Dilator Insertion for Cervical Preparation Prior to Surgical Abortion at 15-18 Weeks | Completed | Society of Family Planning | Phase 3 | 2011-07-01 | In this study the investigators plan to compare mifepristone and misoprostol use to osmotic dilator use for cervical preparation for 15-18 week surgical abortion. Mifepristone would be given 24 hours prior to abortion, and misoprostol 400 mcg would be administered buccally 2 hours prior to abortion. Osmotic dilators are the method currently used in our institution, and are placed 24 hours prior to abortion. The primary outcome will be the length of the procedure. Secondary outcomes will include amount of dilation achieved, ease of procedure, participant's assessment of discomfort before mifepristone or dilators, discomfort during the abortion procedure, acceptability to participants, and acceptability to staff. |
| >Trial ID | >Title | >Status | >Sponsor | >Phase | >Start Date | >Summary |
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