There has not been a prospective, randomized controlled trial of colchicine to reduce post-AF
ablation pericarditis in an era of newer AF ablation techniques. The hypothesis is that an
empiric pre and post AF ablation treatment protocol with colchicine may reduce the incidence
and symptom severity of post-AF ablation related pericarditis. Thus, the goal of this study
is to
1. Identify the incidence of post-AF ablation related pericarditis in patients undergoing
ablation via high power, short duration strategy (shorter total RF time, but increased
stability due to steerable catheters and possible difference from resistive vs
conductive heating).
2. Identify potential differences in patients undergoing PVI only versus PVI + additional
ablation
3. Identify whether patients on who are already on anti-inflammatories such as ASA or
statins have a lower incidence than those without
4. Determine if an empiric treatment strategy with colchicine (for 7 days post ablation)
reduces the incidence of post-operative AF
Colchicine Protective Effect in Patients Undergoing Percutaneous Coronary Intervention (COLCHICINE-PROTECT)
Not yet recruiting
Helwan University
Phase 3
2023-03-01
The goal of this clinical trial is to evaluate the colchicine protective effect in patients
undergoing Percutaneous Coronary Intervention (PCI). The main question it aims to answer is:
does initiating colchicine before planned PCI will reduce post-procedural myocardial injury?
Half of the participants will receive colchicine, while the other half will receive a
placebo.
Drugs may be covered by multiple patents or regulatory protections. All trademarks and applicant names are the property of their respective owners or licensors.
Although great care is taken in the proper and correct provision of this service, thinkBiotech LLC does not accept any responsibility for possible consequences of errors or omissions in the provided data.
The data presented herein is for information purposes only. There is no warranty that the data contained herein is error free.
thinkBiotech performs no independent verification of facts as provided by public sources nor are attempts made to provide legal or investing advice. Any reliance on data provided herein is done solely at the discretion of the user.
Users of this service are advised to seek professional advice and independent confirmation before considering acting on any of the provided information. thinkBiotech LLC reserves the right to amend, extend or withdraw any part or all of the offered service without notice.
Alerts Available With Subscription
Alerts are available for users with active subscriptions.
