Study Evaluating Orally Administered Moxidectin In Subjects With Onchocerca Volvulus Infection
Completed
World Health Organization
Phase 2
2006-09-01
The primary purpose of this study is to determine the safety and tolerability of moxidectin
in subjects infected with O. volvulus with special emphasis on Mazzotti reactions to
determine whether it is safe enough to expose a number of subjects sufficient for obtaining
statistically significant data on the safety and efficacy of moxidectin relative to
ivermectin.
Secondary objects are to determine the pharmacokinetics of moxidectin, to obtain initial
indication of the efficacy in terms of long term effect on skin microfilaria levels and an
indication of the effect on the macrofilaria that may underlie the effect on skin
microfilaria levels.
Study Evaluating Orally Administered Moxidectin In Subjects With Onchocerca Volvulus Infection
Completed
Medicines Development for Global Health
Phase 2
2006-09-01
The primary purpose of this study is to determine the safety and tolerability of moxidectin
in subjects infected with O. volvulus with special emphasis on Mazzotti reactions to
determine whether it is safe enough to expose a number of subjects sufficient for obtaining
statistically significant data on the safety and efficacy of moxidectin relative to
ivermectin.
Secondary objects are to determine the pharmacokinetics of moxidectin, to obtain initial
indication of the efficacy in terms of long term effect on skin microfilaria levels and an
indication of the effect on the macrofilaria that may underlie the effect on skin
microfilaria levels.
Study Evaluating The Effect Of High-Fat Meal On Bioavailability And Pharmacokinetics Of Single Dose Of Moxidectin
Completed
Wyeth is now a wholly owned subsidiary of Pfizer
Phase 1
2008-11-01
The primary objective of this study is to assess the effect of a high-fat meal (breakfast) on
the concentrations of moxidectin measured in the blood after a single oral administration in
healthy subjects.
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