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Last Updated: November 4, 2024

CLINICAL TRIALS PROFILE FOR NESACAINE-MPF


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All Clinical Trials for NESACAINE-MPF

Trial ID Title Status Sponsor Phase Start Date Summary
NCT00845962 ↗ A Comparison of Bupivacaine and 2-chloroprocaine for Spinal Anesthesia Completed Centre hospitalier de l'Université de Montréal (CHUM) N/A 2009-02-01 The purpose of this study is to compare the efficacity and the readiness for discharge between two local anesthetics, bupivacaine and 2-chloroprocaine, used for spinal anesthesia.
NCT00845962 ↗ A Comparison of Bupivacaine and 2-chloroprocaine for Spinal Anesthesia Completed Université de Montréal N/A 2009-02-01 The purpose of this study is to compare the efficacity and the readiness for discharge between two local anesthetics, bupivacaine and 2-chloroprocaine, used for spinal anesthesia.
NCT02862912 ↗ Chloroprocaine Spinal Anesthesia for Cervical Cerclage (CP Spinal) Completed Columbia University Phase 4 2016-11-08 This study aims to determine whether or not spinal anesthesia with the local anesthetic drug, chloroprocaine, wears off faster than the local anesthetic drug, bupivacaine, and results in faster discharge from the post-anesthesia care unit after surgery.
NCT03260972 ↗ Intraabdominal Chloroprocaine During Cesarean Delivery for Pain Control Withdrawn Johns Hopkins University Phase 3 2021-06-01 Objective The objective of this study is to test the hypothesis that instillation of intra-abdominal chloroprocaine during cesarean deliveries is associated with decreased postoperative pain and nausea compared to placebo, without increasing intraoperative and postoperative complications. Methods The investigators plan to randomize about 150 women undergoing primary and repeat cesarean deliveries to intra-abdominal chloroprocaine versus placebo prior to abdominal closure. Women will be excluded if they have ascertained or presumptive hypersensitivity to the ester type and major anesthetics; if they have chronic pelvic pain or if they refuse to participate in the study. The investigators' primary outcome measure will be postoperative pain as measured by visual analogue scale (VAS) at 1 hour after skin closure. Secondary outcomes will include objective pain as measured by VAS at 2, 6, 24 and 48 hours at rest and during mobilization, adverse effects of chloroprocaine (gastrointestinal side effects, pruritus), concomitant analgesic requirement, hospital readmissions and length of hospital stay. Analysis will follow the intention-to-treat principle. The investigators will also be studying the concentration/effect (PKPD) relationship of chloroprocaine use for pain control in the postpartum period. The time courses of the plasma concentrations of chloroprocaine will be analyzed with mixed effects pharmacokinetic-pharmacodynamic (PKPD).
>Trial ID >Title >Status >Phase >Start Date >Summary

Clinical Trial Conditions for NESACAINE-MPF

Condition Name

Condition Name for NESACAINE-MPF
Intervention Trials
Cerclage, Cervical 1
Cesarean Section 1
Cesarean Section Complications 1
Maternal Care for Cervical Incompetence 1
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Condition MeSH

Condition MeSH for NESACAINE-MPF
Intervention Trials
Uterine Cervical Incompetence 1
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Clinical Trial Locations for NESACAINE-MPF

Trials by Country

Trials by Country for NESACAINE-MPF
Location Trials
United States 5
Canada 1
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Trials by US State

Trials by US State for NESACAINE-MPF
Location Trials
Arkansas 2
North Carolina 1
Oregon 1
New York 1
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Clinical Trial Progress for NESACAINE-MPF

Clinical Trial Phase

Clinical Trial Phase for NESACAINE-MPF
Clinical Trial Phase Trials
Phase 4 2
Phase 3 1
N/A 1
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Clinical Trial Status

Clinical Trial Status for NESACAINE-MPF
Clinical Trial Phase Trials
Completed 4
Withdrawn 1
Active, not recruiting 1
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Clinical Trial Sponsors for NESACAINE-MPF

Sponsor Name

Sponsor Name for NESACAINE-MPF
Sponsor Trials
University of Arkansas 2
Oregon Health and Science University 1
Duke University 1
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Sponsor Type

Sponsor Type for NESACAINE-MPF
Sponsor Trials
Other 8
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