A Compassionate Treatment Protocol for the Use of Trimetrexate Glucuronate (Neutrexin) With Leucovorin Protection for European Adult Patients (>= 13 Years Old) With Pneumocystis Carinii Pneumonia
Completed
U.S. Bioscience
N/A
1969-12-31
To evaluate the safety and efficacy of trimetrexate glucuronate with leucovorin protection in
European patients with Pneumocystis carinii pneumonia (PCP) who are refractory to or have
demonstrated severe or life-threatening toxicities to standard therapies (e.g., TMP/SMX or
parenteral pentamidine).
A Study of Trimetrexate Plus Leucovorin in Children With Pneumocystis Carinii Pneumonia
Completed
U.S. Bioscience
N/A
1969-12-31
To evaluate the safety and efficacy of trimetrexate glucuronate with leucovorin protection in
pediatric patients with Pneumocystis carinii pneumonia (PCP) who are refractory to or have
demonstrated severe or life-threatening toxicities to standard therapies (e.g., TMP/SMX or
parenteral pentamidine).
A Study of Neutrexin Plus Leucovorin in the Treatment of Pneumocystis Carinii Pneumonia (PCP)
Completed
U.S. Bioscience
N/A
1969-12-31
To evaluate the safety and efficacy of trimetrexate glucuronate with leucovorin protection in
patients with Pneumocystis carinii pneumonia (PCP) who are refractory to or have demonstrated
severe or life-threatening toxicities to standard therapies (e.g., TMP/SMX or parenteral
pentamidine).
Chemotherapy in Treating Patients With Recurrent or Metastatic Colorectal Cancer
Completed
Grupo Oncologico Cooperativo del Sur
Phase 2
1997-12-01
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so
they stop growing or die. Combining more than one drug may kill more tumor cells.
PURPOSE: Phase II trial to study the effectiveness of trimetrexate glucuronate, fluorouracil,
and leucovorin in treating patients with recurrent or metastatic colorectal cancer.
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