CLINICAL TRIALS PROFILE FOR NIACIN
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All Clinical Trials for NIACIN
| Trial ID | Title | Status | Sponsor | Phase | Start Date | Summary |
|---|---|---|---|---|---|---|
| NCT00000461 ↗ | Harvard Atherosclerosis Reversibility Project (HARP) | Completed | National Heart, Lung, and Blood Institute (NHLBI) | Phase 2 | 1986-12-01 | To determine by sequential coronary arteriography whether a lipid-lowering diet with and without lipid-lowering drugs could reverse coronary artery disease in normocholesterolemic patients. Also, to test whether fish oil supplements could improve human coronary atherosclerosis. Finally, to determine the effect of combination therapy with lipid-reducing drugs in patients with coronary heart disease and "normal" cholesterol levels. At least three clinical trials were conducted. |
| NCT00000482 ↗ | Coronary Drug Project | Completed | National Heart, Lung, and Blood Institute (NHLBI) | Phase 3 | 1965-04-01 | To determine whether regular administration of lipid modifying drugs (clofibrate, nicotinic acid, estrogen, dextrothyroxine) to men with a documented myocardial infarction would result in significant reduction in total mortality over a five year period. Secondarily, to determine whether the degree to which these drugs changed serum lipids was correlated with any effect on mortality and morbidity rates; to gain further information on the long-term prognosis of myocardial infarction (by studying the control group as intensively as the treatment group); to acquire further experience and knowledge concerning the techniques and methodology of long-term clinical trials; to determine, in a substudy, the effectiveness of aspirin, a platelet inhibitor, in reducing recurrences of myocardial infarction. |
| NCT00000483 ↗ | Coronary Drug Project Mortality Surveillance | Completed | National Heart, Lung, and Blood Institute (NHLBI) | N/A | 1981-06-01 | To determine whether there were any long term sequelae of the drugs used in the Coronary Drug Project (estrogens, dextrothyroxine, nicotinic acid, clofibrate). |
| NCT00000512 ↗ | Familial Atherosclerosis Treatment Study | Completed | National Heart, Lung, and Blood Institute (NHLBI) | Phase 3 | 1984-01-01 | To compare the effects of two intensive lipid-lowering regimens with conventional therapy on coronary atherosclerosis as assessed by arteriography. |
| NCT00000512 ↗ | Familial Atherosclerosis Treatment Study | Completed | University of Washington | Phase 3 | 1984-01-01 | To compare the effects of two intensive lipid-lowering regimens with conventional therapy on coronary atherosclerosis as assessed by arteriography. |
| NCT00000539 ↗ | Arterial Disease Multifactorial Intervention Trial (ADMIT) | Completed | National Heart, Lung, and Blood Institute (NHLBI) | Phase 3 | 1992-09-01 | To evaluate, in asymptomatic and symptomatic participants with peripheral arterial disease, the feasibility of recruitment and adherence, efficacy and safety of HDL-C raising along with effective control of LDL-C levels, antioxidant therapy, antithrombotic therapy, and their combinations. |
| NCT00000553 ↗ | HDL-Atherosclerosis Treatment Study (HATS) | Completed | National Heart, Lung, and Blood Institute (NHLBI) | Phase 3 | 1994-09-01 | To measure the effects of lipid-lowering drugs and/or antioxidant vitamins on progression or regression of coronary heart disease as measured by quantitative angiography in patients with low high density lipoprotein (HDL) cholesterol. |
| >Trial ID | >Title | >Status | >Sponsor | >Phase | >Start Date | >Summary |
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