Sodium Nitroprusside for Blood Pressure Reduction in the ICU (SNP2)
Completed
Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Phase 2
2009-01-01
Nitroprusside is used commonly in the Intensive Care Unit for long periods of time in order
to reduce blood pressure. It is not known if the body compensates over time to the blood
pressure lowering, and if when the nitroprusside is stopped the blood pressure goes up at a
faster rate and is higher than it was at the start of the treatment. This study will answer
these questions.
Microcirculatory Impairment in Patients With Leprosy
Completed
Curt Treu
N/A
2006-03-01
In this study the investigators have aimed to evaluate morphology and reactivity of cutaneous
microcirculation in patients with lepromatous leprosy. Ten patients, without any other
comorbidity were compared to ten controls without leprosy or any other comorbidity, using the
Cytoscan® [orthogonal polarization spectral (OPS) imaging], Fourier analysis of laser Doppler
signal to evaluate vasomotion (rhythmic spontaneous oscillation of arteriolar diameter) and
laser Doppler flowmetry associated to iontophoresis of vasoactive substances (acetylcholine
and sodium nitroprusside).
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