A Study to Evaluate the Effects of Different Methods of Birth Control on the Drug Actions of Zidovudine (an Anti-HIV Drug) in HIV-Positive Women and to Compare Zidovudine Metabolism in Men and Women
Completed
National Institute of Allergy and Infectious Diseases (NIAID)
N/A
1969-12-31
The purpose of this study is to look at the effects of different methods of birth control
(oral and injectable) on how the body absorbs, makes available, and removes zidovudine (ZDV).
This study will also evaluate the differences in men and women in how the body absorbs, makes
available, and removes ZDV.
Past research has shown that the effectiveness of ZDV as an anti-HIV drug might be decreased
in individuals who use certain methods of birth control. ZDV may also have different effects
in men compared to women.
Hormone Replacement Therapy and the Risk of Breast Cancer Recurrence in Women With Previous Early Stage Breast Cancer
Completed
European Organisation for Research and Treatment of Cancer - EORTC
Phase 3
1997-09-01
RATIONALE: Hormone replacement therapy is effective for relieving symptoms of menopause. It
is not yet known if hormone replacement therapy increases the risk of breast cancer
recurrence in women previously treated for early stage breast cancer.
PURPOSE: Randomized phase III trial to determine the risk of breast cancer recurrence in
women with previous early stage breast cancer who are receiving hormone replacement therapy
for menopause symptoms.
Hormone Replacement Therapy and the Risk of Breast Cancer Recurrence in Women With Previous Early Stage Breast Cancer
Completed
International Breast Cancer Study Group
Phase 3
1997-09-01
RATIONALE: Hormone replacement therapy is effective for relieving symptoms of menopause. It
is not yet known if hormone replacement therapy increases the risk of breast cancer
recurrence in women previously treated for early stage breast cancer.
PURPOSE: Randomized phase III trial to determine the risk of breast cancer recurrence in
women with previous early stage breast cancer who are receiving hormone replacement therapy
for menopause symptoms.
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