Fecal Transplant +/- Gut Decontamination in Preventing Acute Graft Versus Host Disease in Patients Given Broad-Spectrum Antibiotics
Withdrawn
National Cancer Institute (NCI)
Phase 2
2020-06-01
This phase II trial studies how well a fecal microbiota transplant with or without total gut
decontamination works in preventing graft versus host disease in patients exposed to
broad-spectrum antibiotics. Fecal microbiota transplantation is the administration by enema
of fecal matter (stool) that includes helpful bacteria from a normal, healthy donor. Total
gut decontamination uses antibiotics to remove/reduce the amount of bacteria in the digestive
system. It is not yet known if a fecal microbiota transplant with or without total gut
decontamination works better in preventing graft versus host disease compared to standard
immunosuppressive therapies (therapies that lower the normal function of the immune system).
Fecal Transplant +/- Gut Decontamination in Preventing Acute Graft Versus Host Disease in Patients Given Broad-Spectrum Antibiotics
Withdrawn
M.D. Anderson Cancer Center
Phase 2
2020-06-01
This phase II trial studies how well a fecal microbiota transplant with or without total gut
decontamination works in preventing graft versus host disease in patients exposed to
broad-spectrum antibiotics. Fecal microbiota transplantation is the administration by enema
of fecal matter (stool) that includes helpful bacteria from a normal, healthy donor. Total
gut decontamination uses antibiotics to remove/reduce the amount of bacteria in the digestive
system. It is not yet known if a fecal microbiota transplant with or without total gut
decontamination works better in preventing graft versus host disease compared to standard
immunosuppressive therapies (therapies that lower the normal function of the immune system).
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