CLINICAL TRIALS PROFILE FOR PEMOLINE
✉ Email this page to a colleague
All Clinical Trials for PEMOLINE
| Trial ID | Title | Status | Sponsor | Phase | Start Date | Summary |
|---|---|---|---|---|---|---|
| NCT00000282 ↗ | Pemoline for Cocaine Abuse - 7 | Completed | National Institute on Drug Abuse (NIDA) | Phase 2 | 1994-09-01 | The purpose of this study is to evaluate the treatment of pemoline for cocaine abuse. |
| NCT00000282 ↗ | Pemoline for Cocaine Abuse - 7 | Completed | VA Connecticut Healthcare System | Phase 2 | 1994-09-01 | The purpose of this study is to evaluate the treatment of pemoline for cocaine abuse. |
| NCT00000282 ↗ | Pemoline for Cocaine Abuse - 7 | Completed | Yale University | Phase 2 | 1994-09-01 | The purpose of this study is to evaluate the treatment of pemoline for cocaine abuse. |
| NCT00000340 ↗ | Pemoline in the Treatment of Stimulant Dependence - 5 | Withdrawn | National Institute on Drug Abuse (NIDA) | Phase 2 | 1996-06-01 | The purpose of this study is to assess the efficacy of pemoline in treating cocaine and/or methamphetamine dependent adults with comorbid Adult Attention Deficit Hyperactivity Disorder (ADHD). |
| NCT00220506 ↗ | Fatigue Treatment Using Provigil | Unknown status | Sheba Medical Center | N/A | 2005-09-01 | To determine whether therapy with Modafinal(Provigil) is safe and effective in fatigue in MS Patients |
| NCT00538655 ↗ | A Pilot Trial of Modafinil for Treatment of Methamphetamine Dependence | Completed | California Pacific Medical Center Research Institute | Phase 2 | 2008-01-01 | Patients treated for methamphetamine dependence have high rates of relapse, and no pharmacotherapy has yet been demonstrated to be efficacious. Modafinil (d, l-2-[(diphenylmethyl) sulfinyl] acetamide) is a novel wake- and vigilance- promoting agent that is chemically and pharmacologically dissimilar to CNS stimulants such as the amphetamines, methylphenidate, and pemoline. It is well tolerated and has low abuse liability compared to CNS stimulants. Modafinil is FDA approved for a variety of sleep disorders, may relieve methamphetamine withdrawal symptoms, improves cognitive function, has been shown to reduce cocaine use in dependent users, and is safe when co-administered with intravenous methamphetamine. We will conduct a pilot, open-label clinical trial of modafinil to establish its safety and efficacy as a pharmacotherapy for methamphetamine dependence. Specific Aims: 1. Determine the safety of modafinil in the treatment of methamphetamine dependence. 2. Determine the efficacy of modafinil in the treatment of methamphetamine dependence. 3. Assess the effect of modafinil on cognitive function in methamphetamine users. 4. Assess the effect of modafinil on methamphetamine withdrawal symptoms. 5. Compare the validity of a cellular telephone-based reporting system for assessing medication regimen adherence to conventional electronic medication monitoring. Hypotheses: 1. Modafinil will be as safe and well tolerated as placebo in a comparison group from another study. 2. Subjects given modafinil will use less methamphetamine than subjects given placebo. 3. Subjects given modafinil with demonstrate improvements in cognitive function when compared to subjects given placebo. 4. Subjects given modafinil will have reduced withdrawal symptoms when compared to subjects given placebo. 5. Adherence will be recorded more accurately by cellular telephone than by conventional electronic medication monitoring. |
| >Trial ID | >Title | >Status | >Sponsor | >Phase | >Start Date | >Summary |
Clinical Trial Conditions for PEMOLINE
Condition Name
Clinical Trial Locations for PEMOLINE
Trials by Country
Clinical Trial Progress for PEMOLINE
Clinical Trial Phase
Clinical Trial Sponsors for PEMOLINE
Sponsor Name
