A Comparative Study of the Efficacy of Penciclovir 10mg/g (1%) Cream in Preventing the Appearance of Classical Lesion in Recurrent Cold Sore Sufferers
Completed
Novartis
Phase 4
2008-12-01
Comparison of the efficacy of penciclovir 10 mg/g (1%) cream with that of vehicle at 72 hours
in preventing the appearance of classical lesions following prodromal symptoms (tingling or
burning sensation) based on thermographic assessment among recurrent cold sore sufferers.
Non-inferiority Comparison of Efficacy and Safety of Penciclovir 10mg/g to Acyclovir 50mg/g in the Treatment of Recurrent Herpes Labialis
Completed
EMS
Phase 3
2012-02-01
Herpes labialis is the most common recurrent manifestation of herpes simplex. The purpose of
this study is to check the non-inferiority efficacy and safety of penciclovir 10mg/g as
treatment for Herpes Labialis in comparison to acyclovir 50mg/g.
A Phase 2, Muti-Center Study of Repeat Dosing of Squaric Acid Dibutyl Ester in Subjects With Herpes Labialis
Terminated
Squarex, LLC
Phase 2
2018-03-12
Primary Objective: To assess local and generalized adverse events with repeat topical
application of 2% and 0.5% squaric acid dibutyl ester (SADBE) in subjects with frequent
herpes labialis (4 or more episodes in the previous 12 months).
Secondary Objective: To assess efficacy of repeat topical application of 2% and 0.5% SADBE in
the prevention of herpes labialis episodes.
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