Cyproheptadine and Megestrol in Preventing Weight Loss in Children With Cachexia Caused By Cancer or Cancer Treatment
Completed
National Cancer Institute (NCI)
Phase 2
2003-06-01
RATIONALE: Cyproheptadine and megestrol may improve appetite and help prevent weight loss in
children with cancer.
PURPOSE: This phase II trial is studying how well cyproheptadine and megestrol work in
improving appetite and preventing weight loss in children with cachexia caused by cancer or
cancer treatment.
Cyproheptadine and Megestrol in Preventing Weight Loss in Children With Cachexia Caused By Cancer or Cancer Treatment
Completed
University of South Florida
Phase 2
2003-06-01
RATIONALE: Cyproheptadine and megestrol may improve appetite and help prevent weight loss in
children with cancer.
PURPOSE: This phase II trial is studying how well cyproheptadine and megestrol work in
improving appetite and preventing weight loss in children with cachexia caused by cancer or
cancer treatment.
A Placebo-controlled Crossover Trial Using Cyproheptadine To Treat Children With Functional Abdominal Pain
Terminated
University of Michigan
Phase 2
2012-08-01
The investigators hypothesize that using Cyproheptadine in a placebo-controlled crossover
trial would help relieve abdominal pain associated with (Functional Abdominal Pain (FAP) in
children, achieving a greater response than that observed with placebo. In addition to
assessing self-report of pain and other symptoms, the investigators also propose to perform
experimental somatic pain testing to determine if there is evidence of
peripherally-maintained central sensitization in children with FAP. The investigators also
hypothesize that there will be an increase in somatic pain threshold after completion of a
Cyproheptadine course compared to baseline testing prior to treatment, and compared to
placebo. This would allow children with FAP to return to normal function, improve symptoms
and overall general well-being
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