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Last Updated: November 22, 2024

CLINICAL TRIALS PROFILE FOR PLENDIL


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All Clinical Trials for PLENDIL

Trial ID Title Status Sponsor Phase Start Date Summary
NCT01238705 ↗ Combined Antihypertensive Therapy and Sexual Dysfunction Unknown status LanZhou University Phase 4 2008-04-01 This randomized,active controlled study aimed to compare the effects on sexual function of treatment with combined antihypertensive drugs. The researchers hypothesize that: 1. Both felodipine-irbesartan combination and felodipine-metoprolol combination are effective in lowing blood pressure in patients with essential hypertension. 2. Felodipine-metoprolol combination induces a worse sexual function and a reduction of sex hormone,whereas felodipine-irbesartan combination does not impair sexual function and does not change hormone levels. 3. Oxidative stress decline after both combination regimens. Felodipine-irbesartan combination has a greater impact on oxidative stress indicators than felodipine-metoprolol combination.
NCT02232269 ↗ Coffee Interaction With the Antihypertensive Drug Felodipine Completed Lawson Health Research Institute Phase 1 2012-02-01 Coffee is a globally popular beverage. More than half of the United States population spends an estimated $ 40 billion on the purchase of coffee each year. Personal consumption habits can vary. For example, the frequency of ingestion ranged from 59% for every day to 8% for less than one day per week consumption in one survey. In the case of occasional consumption, coffee can markedly elevate blood pressure in normotensive and hypertensive individuals. This pressor effect can occur with a caffeine dose of 200 - 250 mg, which can be found 2 - 3 cups of coffee. A major active constituent in coffee is caffeine, which is the most widely used pharmacological substance in the world. Drug therapy plays a major role in the management of hypertension. However, the interaction between coffee or caffeine and blood pressure lowering drugs has been assessed in only three clinical studies that were reported more than three decades ago. We conducted a comprehensive interaction study involving a commonly ingested amount of a particular Colombian coffee and felodipine in healthy middle-aged men and women. Peripheral (brachial) and central (aortic) hemodynamics and caffeine and felodipine pharmacokinetics were evaluated.
NCT02311530 ↗ Bioequivalence Study of Felodipine ER Tablets 10 mg Under Fed Conditions Completed Ranbaxy Laboratories Limited N/A 2008-10-01 The study was conducted as an open-label, balanced, randomized, two-treatment, two-period, two-sequence, single-dose, crossover, bioequivalence study comparing felodipine extended release tablets USP 10 mg (containing felodipine 10 mg) manufactured by OHM Laboratories Inc., NJ, 08901 with PLENDILĀ® extended release tablets 10 mg (containing felodipine 10 mg) manufactured by Merck & Co. Inc. Whitehouse Station, NJ 08889 USA for AstraZeneca LP Wilmington, DE 19850 in healthy, adult, male, human subjects under fed condition.
NCT02327247 ↗ Bioequivalence Study of Felodipine ER Tablets 10 mg Under Fasting Conditions Completed Ranbaxy Laboratories Limited N/A 2008-09-01 The study was conducted as an open-label, balanced, randomized, two-treatment, two-period, two-sequence, single-dose, crossover, bioequivalence study comparing Felodipine extended release tablets USP 10 mg (containing felodipine 10 mg) manufactured by OHM Laboratories, Inc., NJ, 08901 with PLENDILĀ® extended release tablets 10 mg (containing felodipine 10 mg) manufactured by Merck & Co. Inc. Whitehouse Station, NJ 08889 USA for AstraZeneca LP Wilmington, DE 19850 in healthy, adult, male, human subjects under fasting condition.
>Trial ID >Title >Status >Phase >Start Date >Summary

Clinical Trial Conditions for PLENDIL

Condition Name

Condition Name for PLENDIL
Intervention Trials
Healthy 2
Food-Drug Interactions 1
Hypertension 1
Sexual Dysfunction 1
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Condition MeSH

Condition MeSH for PLENDIL
Intervention Trials
Malnutrition 1
Hypertension 1
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Clinical Trial Locations for PLENDIL

Trials by Country

Trials by Country for PLENDIL
Location Trials
Canada 1
China 1
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Clinical Trial Progress for PLENDIL

Clinical Trial Phase

Clinical Trial Phase for PLENDIL
Clinical Trial Phase Trials
Phase 4 1
Phase 1 1
N/A 2
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Clinical Trial Status

Clinical Trial Status for PLENDIL
Clinical Trial Phase Trials
Completed 3
Unknown status 1
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Clinical Trial Sponsors for PLENDIL

Sponsor Name

Sponsor Name for PLENDIL
Sponsor Trials
Ranbaxy Laboratories Limited 2
LanZhou University 1
Lawson Health Research Institute 1
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Sponsor Type

Sponsor Type for PLENDIL
Sponsor Trials
Other 2
Industry 2
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