Safety and Efficacy of Probuphine in the Treatment of Opioid Dependence
Completed
Titan Pharmaceuticals
Phase 3
2006-10-01
Buprenorphine (BPN) is an approved treatment for opioid dependence, however, in taking oral
tablets, patients experience withdrawal and cravings when the variable BPN levels in the
blood are low. Probuphine is an implant placed just beneath the skin that contains BPN. It is
designed to provide 6 months of stable BPN blood levels. This study will test the safety and
efficacy of Probuphine in the treatment of patients with opioid dependence.
Extension to Safety and Efficacy of Probuphine in the Treatment of Opioid Dependence
Completed
Titan Pharmaceuticals
Phase 3
2007-10-01
Buprenorphine (BPN) is an approved treatment for opioid dependence; however, in taking oral
tablets, patients experience withdrawal and cravings when the variable BPN levels in the
blood are low. Probuphine (buprenorphine implant) is an implant placed just beneath the skin
that contains BPN. It is designed to provide 6 months of stable BPN blood levels. This study
will test the safety and efficacy of Probuphine in the treatment of patient with opioid
dependence. Patients who have completed 24 weeks of treatment in the Randomized,
Double-Blind, Placebo-Controlled, Multi-Center Study of Probuphine in Patients with Opioid
Dependence, will be re-treated with Probuphine over an additional 24 weeks.
A Bioavailability and Safety Study of Probuphine Versus Sublingual Buprenorphine in Patients With Opioid Dependence
Terminated
Titan Pharmaceuticals
Phase 3
2008-09-01
This study will measure the amount of buprenorphine found in the blood after taking
sublingual buprenorphine tablets versus after implantation with 4 Probuphine (buprenorphine
implants).
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