Efficacy of Phenytoin vs Levetiracetam in Status Epilepticus at Institute of Child Health,Faisalabad
Completed
Shaheed Zulfiqar Ali Bhutto Medical University
N/A
2022-08-01
Status epilepticus is the second most common neurologic emergency in children. Morbidity and
mortality are considerable; thus, timely termination of convulsive status epilepticus is the
primary goal of management to avoid these risks Our objective was to compare the efficacy of
phenytoin and Levetiracetam in status epilepticus in children.
This study was done in the pediatric emergency department of Children Hospital Faisalabad.
A total of 70 patients were randomly allocated to one of the groups by a computer-generated
random number table according to their admission in an emergency. Children in group A were
given levetiracetam. Children in group B were given I/V phenytoin. For both groups if
seizures recurred after the first loading dose an additional 10mg/kg of the same drug was
given over 10 minutes.
The patients were monitored to see whether there was any recurrence of seizure activity in
the subsequent 24 hours. Seizure control was defined as the absence of seizure within 24
hours after the initial loading of the drug.
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