Comparison of Ro 31-8959 Plus Zidovudine (AZT) Versus AZT Plus Zalcitabine (ddC) Versus Ro 31-8959 Plus AZT Plus ddC
Completed
Hoffmann-La Roche
Phase 2
1969-12-31
PRIMARY: To determine the efficacy and toxicity of three treatment regimens: saquinavir
mesylate (Ro 31-8959) plus zidovudine (AZT) vs. AZT plus zalcitabine (dideoxycytidine; ddC)
vs. Ro 31-8959 plus AZT plus ddC.
SECONDARY: To investigate the pharmacokinetics and effects on various clinical parameters of
the three regimens.
A Dose-Escalating Study of Ro 31-8959 ( HIV Protease Inhibitor ) in Patients With HIV Disease.
Completed
Stanford University
Phase 1
1969-12-31
To investigate the toxicity, antiviral activity, and pharmacokinetics in HIV-infected
patients receiving 16 weeks of oral saquinavir mesylate ( Ro 31-8959 ) at one of two doses.
A Study of Saquinavir and Zalcitabine, Used Alone and Together, in the Treatment of Advanced HIV Infection in Patients Who Stopped Taking or Who Cannot Take Zidovudine
Completed
Hoffmann-La Roche
Phase 2
1969-12-31
To compare the safety, tolerance, and efficacy of saquinavir mesylate (Ro 31-8959) alone,
zalcitabine (dideoxycytidine; ddC) alone, and both in combination, in patients discontinuing
or unable to take zidovudine (AZT).
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