Introduction to SCANDONEST Plain
SCANDONEST Plain, containing the active ingredient mepivacaine hydrochloride, is a local anesthetic widely used in dental procedures. It is known for its rapid onset and effective duration of anesthesia, making it a preferred choice for dental practitioners.
Clinical Description and Indications
SCANDONEST Plain is indicated for the production of local anesthesia through infiltration or nerve block in adults and pediatric patients. It is particularly useful for dental procedures, providing operative anesthesia for both the upper and lower jaws[2].
Clinical Trials Update
While specific ongoing clinical trials for SCANDONEST Plain itself may not be extensively detailed, it is important to note that mepivacaine, as a well-established local anesthetic, is often part of broader studies comparing different anesthetics.
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Comparative Studies: Recent studies have compared the efficacy of mepivacaine with other local anesthetics like articaine. For instance, a study assessing the success rate of inferior alveolar nerve blocks found that mepivacaine had a success rate of 35.8% compared to articaine's 41.2% in patients with symptomatic irreversible pulpitis[4].
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Safety and Efficacy: Clinical trials and studies have consistently shown that mepivacaine is safe and effective when used according to the recommended dosages and administration techniques. However, as with any local anesthetic, there are potential risks such as methemoglobinemia, especially in susceptible patients[2].
Market Analysis
Market Presence and Usage
SCANDONEST Plain is marketed by Septodont, Inc., and is available in various formulations, including 3% plain and 2% with levonordefrin. The drug is widely used in dental clinics globally due to its reliability and efficacy.
Competitive Landscape
The market for local anesthetics in dentistry is competitive, with several other products available, such as articaine and lidocaine. However, SCANDONEST Plain maintains a strong position due to its rapid onset and long duration of action.
- Key Competitors: Articaine, another popular local anesthetic, is often compared to mepivacaine in clinical studies. While articaine may have a slightly higher success rate in certain procedures, mepivacaine's stability and lower incidence of systemic toxicity make it a preferred choice for many practitioners[4].
Market Trends
The demand for local anesthetics in dentistry is driven by the increasing need for pain-free dental procedures. With advancements in dental care and an aging population requiring more dental interventions, the market for local anesthetics like SCANDONEST Plain is expected to grow.
Market Projections
Growth Potential
The global market for local anesthetics is projected to grow due to several factors:
- Increasing Dental Procedures: The rise in dental procedures, both cosmetic and therapeutic, is expected to drive the demand for effective local anesthetics.
- Aging Population: An aging population with greater dental needs will contribute to the growth of the market.
- Advancements in Dental Care: Improvements in dental care and the emphasis on pain-free procedures will continue to support the demand for reliable local anesthetics like SCANDONEST Plain.
Regional Market Analysis
The market for SCANDONEST Plain is global, with significant presence in regions with advanced dental care systems.
- North America and Europe: These regions have a high demand for local anesthetics due to the high volume of dental procedures and the emphasis on patient comfort.
- Emerging Markets: Countries in Asia and Latin America are also seeing an increase in dental care services, which is expected to drive the growth of the local anesthetic market.
Safety and Precautions
Common Adverse Reactions
SCANDONEST Plain, like other amide-type local anesthetics, can cause systemic adverse reactions involving the central nervous system and cardiovascular system, especially at high plasma levels. These reactions are typically due to excessive dosage, rapid absorption, or slow metabolic degradation[2].
Special Precautions
- Methemoglobinemia: There is a risk of methemoglobinemia, particularly in patients with glucose-6-phosphate dehydrogenase deficiency or other susceptible conditions. Close monitoring is recommended in such cases[2].
- Allergic Reactions: The formulation with levonordefrin contains potassium metabisulfite, which can cause allergic-type reactions, including anaphylactic symptoms, especially in asthmatic patients[2].
Dosage and Administration
Recommended Dosages
The recommended dosage of SCANDONEST Plain varies depending on the procedure and the patient's age and weight. For dental procedures, the typical dosage is 3% plain or 2% with levonordefrin. The maximum recommended dose is 400 mg (or 6.7 mg/kg) for adults and 2.7 mg/kg for pediatric patients[2].
Administration Techniques
SCANDONEST Plain can be administered through infiltration or nerve block. The onset of action is rapid, typically within 30 seconds to 4 minutes, and the duration of anesthesia can last from 20 minutes in the upper jaw to 40 minutes in the lower jaw[2].
Key Takeaways
- Clinical Trials: While specific trials on SCANDONEST Plain may be limited, comparative studies with other anesthetics highlight its efficacy and safety.
- Market Analysis: SCANDONEST Plain has a strong market presence due to its reliability and long duration of action.
- Market Projections: The market is expected to grow driven by increasing dental procedures and an aging population.
- Safety and Precautions: Close monitoring is necessary for potential adverse reactions like methemoglobinemia and allergic reactions.
FAQs
What is SCANDONEST Plain used for?
SCANDONEST Plain is used for the production of local anesthesia in dental procedures through infiltration or nerve block in adults and pediatric patients.
What are the common adverse reactions associated with SCANDONEST Plain?
Common adverse reactions include systemic effects on the central nervous system and cardiovascular system, methemoglobinemia, and allergic reactions, especially in patients with sulfite sensitivity.
How long does the anesthesia provided by SCANDONEST Plain last?
The anesthesia provided by SCANDONEST Plain typically lasts 20 minutes in the upper jaw and 40 minutes in the lower jaw.
Can SCANDONEST Plain be used in pediatric patients?
Yes, SCANDONEST Plain can be used in pediatric patients, but great care must be exercised in adhering to safe concentrations and dosages.
What is the maximum recommended dose of SCANDONEST Plain?
The maximum recommended dose is 400 mg (or 6.7 mg/kg) for adults and 2.7 mg/kg for pediatric patients.
Sources
- Ozmosi: Mepivacaine Drug Profile.
- DailyMed: SCANDONEST 3% PLAIN - mepivacaine hydrochloride injection, solution.
- Annual Reports: Revance Therapeutics, Inc. - Annual Reports.
- Wiley Online Library: Inferior alveolar nerve block success of 2% mepivacaine versus 4% articaine.
- DMI: Summary of Product Characteristics - SCANDONEST 3% PLAIN.
